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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cortisol awakening response is decreased in patients with first-episode psychosis and increased in healthy controls with a history of severe childhood abuse
|
|---|---|
| Published in |
Schizophrenia Research, May 2018
|
| DOI | 10.1016/j.schres.2018.05.002 |
| Pubmed ID | |
| Authors |
Simone Ciufolini, Charlotte Gayer-Anderson, Helen L Fisher, Tiago Reis Marques, Heather Taylor, Marta Di Forti, Patricia Zunszain, Craig Morgan, Robin M Murray, Carmine M Pariante, Paola Dazzan, Valeria Mondelli |
| Abstract |
Childhood abuse is highly prevalent in psychosis patients, but whether/how it affects hypothalamic-pituitary-adrenal (HPA) axis at the onset of psychosis remains unclear. We aimed to investigate the effects of severity of childhood abuse on HPA axis activity, in first-episode psychosis (FEP) and healthy controls. We recruited 169 FEP patients and 133 controls with different degrees of childhood physical and sexual abuse (i.e. no abuse exposure, non-severe abuse exposure, and severe abuse exposure). Saliva samples were collected to measure cortisol awakening response with respect to ground (CARg), increase (CARi) and diurnal (CDD) cortisol levels. Two-way ANOVA analyses were conducted to test the relationships between severity of childhood abuse and psychosis on cortisol levels in individuals with psychosis and healthy controls with and without childhood abuse history. A statistically significant interaction between childhood abuse and psychosis on CARg was found (F(2,262) = 4.60, p = 0.011, ω2 = 0.42). Overall, controls showed a U-shaped relationship between abuse exposure and CARg, while patients showed an inverted U-shaped relationship. CARg values were markedly different between patients and controls with either no abuse history or exposure to severe childhood abuse. No significant differences were found when looking at CARi and CDD. Our results show a divergent effect of severe childhood abuse on HPA axis activity in patients with first-episode psychosis and in controls. In the presence of exposure to severe childhood abuse, a blunted CARg and a less reactive HPA axis may represent one of the biological mechanisms involved in the development of psychosis. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 8 | 35% |
| United States | 2 | 9% |
| Canada | 2 | 9% |
| Norway | 1 | 4% |
| Australia | 1 | 4% |
| Italy | 1 | 4% |
| Unknown | 8 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 12 | 52% |
| Members of the public | 7 | 30% |
| Practitioners (doctors, other healthcare professionals) | 4 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 102 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 19% |
| Student > Bachelor | 13 | 13% |
| Researcher | 12 | 12% |
| Student > Ph. D. Student | 8 | 8% |
| Unspecified | 6 | 6% |
| Other | 16 | 16% |
| Unknown | 28 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 24 | 24% |
| Medicine and Dentistry | 16 | 16% |
| Neuroscience | 10 | 10% |
| Unspecified | 6 | 6% |
| Nursing and Health Professions | 5 | 5% |
| Other | 5 | 5% |
| Unknown | 36 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2018.
All research outputs
#2,694,405
of 25,382,440 outputs
Outputs from Schizophrenia Research
#519
of 5,687 outputs
Outputs of similar age
#53,929
of 344,113 outputs
Outputs of similar age from Schizophrenia Research
#17
of 152 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,687 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,113 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 152 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.