Title |
Postural Tachycardia Syndrome: Beyond Orthostatic Intolerance
|
---|---|
Published in |
Current Neurology and Neuroscience Reports, July 2015
|
DOI | 10.1007/s11910-015-0583-8 |
Pubmed ID | |
Authors |
Emily M. Garland, Jorge E. Celedonio, Satish R. Raj |
Abstract |
Postural tachycardia syndrome (POTS) is a form of chronic orthostatic intolerance for which the hallmark physiological trait is an excessive increase in heart rate with assumption of upright posture. The orthostatic tachycardia occurs in the absence of orthostatic hypotension and is associated with a >6-month history of symptoms that are relieved by recumbence. The heart rate abnormality and orthostatic symptoms should not be caused by medications that impair autonomic regulation or by debilitating disorders that can cause tachycardia. POTS is a "final common pathway" for a number of overlapping pathophysiologies, including an autonomic neuropathy in the lower body, hypovolemia, elevated sympathetic tone, mast cell activation, deconditioning, and autoantibodies. Not only may patients be affected by more than one of these pathophysiologies but also the phenotype of POTS has similarities to a number of other disorders, e.g., chronic fatigue syndrome, Ehlers-Danlos syndrome, vasovagal syncope, and inappropriate sinus tachycardia. POTS can be treated with a combination of non-pharmacological approaches, a structured exercise training program, and often some pharmacological support. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 9 | 30% |
India | 1 | 3% |
Finland | 1 | 3% |
Australia | 1 | 3% |
Colombia | 1 | 3% |
Canada | 1 | 3% |
United Kingdom | 1 | 3% |
Unknown | 15 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 26 | 87% |
Scientists | 2 | 7% |
Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Korea, Republic of | 1 | <1% |
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Unknown | 188 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 29 | 15% |
Student > Bachelor | 25 | 13% |
Other | 22 | 12% |
Student > Master | 20 | 10% |
Student > Ph. D. Student | 12 | 6% |
Other | 36 | 19% |
Unknown | 47 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 69 | 36% |
Nursing and Health Professions | 22 | 12% |
Neuroscience | 18 | 9% |
Biochemistry, Genetics and Molecular Biology | 8 | 4% |
Agricultural and Biological Sciences | 6 | 3% |
Other | 18 | 9% |
Unknown | 50 | 26% |