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Mendeley readers
Attention Score in Context
| Title |
Importance of disrupted intestinal barrier in inflammatory bowel diseases
|
|---|---|
| Published in |
Inflammatory Bowel Diseases, August 2010
|
| DOI | 10.1002/ibd.21403 |
| Pubmed ID | |
| Authors |
Sa'ad Y. Salim, Johan D. Söderholm |
| Abstract |
The current paradigm of inflammatory bowel diseases (IBD), both Crohn's disease (CD) and ulcerative colitis (UC), involves the interaction between environmental factors in the intestinal lumen and inappropriate host immune responses in genetically predisposed individuals. The intestinal mucosal barrier has evolved to maintain a delicate balance between absorbing essential nutrients while preventing the entry and responding to harmful contents. In IBD, disruptions of essential elements of the intestinal barrier lead to permeability defects. These barrier defects exacerbate the underlying immune system, subsequently resulting in tissue damage. The epithelial phenotype in active IBD is very similar in CD and UC. It is characterized by increased secretion of chloride and water, leading to diarrhea, increased permeability via both the transcellular and paracellular routes, and increased apoptosis of epithelial cells. The main cytokine that seems to drive these changes is tumor necrosis factor alpha in CD, whereas interleukin (IL)-13 may be more important in UC. Therapeutic restoration of the mucosal barrier would provide protection and prevent antigenic overload due to intestinal "leakiness." Here we give an overview of the key players of the intestinal mucosal barrier and review the current literature from studies in humans and human systems on mechanisms underlying mucosal barrier dysfunction in IBD. |
Mendeley readers
The data shown below were compiled from readership statistics for 421 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| Costa Rica | 1 | <1% |
| Belgium | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 413 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 69 | 16% |
| Student > Bachelor | 65 | 15% |
| Student > Master | 50 | 12% |
| Researcher | 40 | 10% |
| Student > Doctoral Student | 37 | 9% |
| Other | 70 | 17% |
| Unknown | 90 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 95 | 23% |
| Agricultural and Biological Sciences | 72 | 17% |
| Biochemistry, Genetics and Molecular Biology | 60 | 14% |
| Immunology and Microbiology | 42 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 3% |
| Other | 37 | 9% |
| Unknown | 101 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2018.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Inflammatory Bowel Diseases
#1,752
of 3,731 outputs
Outputs of similar age
#38,149
of 104,198 outputs
Outputs of similar age from Inflammatory Bowel Diseases
#7
of 26 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,731 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 104,198 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.