Title |
A Robust e-Epidemiology Tool in Phenotyping Heart Failure with Differentiation for Preserved and Reduced Ejection Fraction: the Electronic Medical Records and Genomics (eMERGE) Network
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Published in |
Journal of Cardiovascular Translational Research, July 2015
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DOI | 10.1007/s12265-015-9644-2 |
Pubmed ID | |
Authors |
Suzette J. Bielinski, Jyotishman Pathak, David S. Carrell, Paul Y. Takahashi, Janet E. Olson, Nicholas B. Larson, Hongfang Liu, Sunghwan Sohn, Quinn S. Wells, Joshua C. Denny, Laura J. Rasmussen-Torvik, Jennifer Allen Pacheco, Kathryn L. Jackson, Timothy G. Lesnick, Rachel E. Gullerud, Paul A. Decker, Naveen L. Pereira, Euijung Ryu, Richard A. Dart, Peggy Peissig, James G. Linneman, Gail P. Jarvik, Eric B. Larson, Jonathan A. Bock, Gerard C. Tromp, Mariza de Andrade, Véronique L. Roger |
Abstract |
Identifying populations of heart failure (HF) patients is paramount to research efforts aimed at developing strategies to effectively reduce the burden of this disease. The use of electronic medical record (EMR) data for this purpose is challenging given the syndromic nature of HF and the need to distinguish HF with preserved or reduced ejection fraction. Using a gold standard cohort of manually abstracted cases, an EMR-driven phenotype algorithm based on structured and unstructured data was developed to identify all the cases. The resulting algorithm was executed in two cohorts from the Electronic Medical Records and Genomics (eMERGE) Network with a positive predictive value of >95 %. The algorithm was expanded to include three hierarchical definitions of HF (i.e., definite, probable, possible) based on the degree of confidence of the classification to capture HF cases in a whole population whereby increasing the algorithm utility for use in e-Epidemiologic research. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 80 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 26% |
Student > Ph. D. Student | 12 | 15% |
Professor > Associate Professor | 6 | 7% |
Student > Bachelor | 5 | 6% |
Student > Doctoral Student | 4 | 5% |
Other | 18 | 22% |
Unknown | 15 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 30 | 37% |
Computer Science | 9 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Agricultural and Biological Sciences | 4 | 5% |
Nursing and Health Professions | 3 | 4% |
Other | 9 | 11% |
Unknown | 21 | 26% |