Title |
The motor and cognitive features of Parkinson’s disease in patients with concurrent Gaucher disease over 2 years: a case series
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Published in |
Journal of Neurology, May 2018
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DOI | 10.1007/s00415-018-8908-6 |
Pubmed ID | |
Authors |
Lucy M. Collins, Caroline H. Williams-Gray, Elizabeth Morris, Patrick Deegan, Timothy M. Cox, Roger A. Barker |
Abstract |
We report the cognitive features and progression of Parkinson's disease (PD) in five patients with concurrent Gaucher disease. The patients presented at an earlier age than patients with sporadic PD, as previously noted by others; but in contrast to many previous reports, our patients followed a variable clinical course. While two patients developed early cognitive deficits and dementia, three others remained cognitively intact over the follow-up period. Thus, in this small case series, PD in the context of GD more closely resembles idiopathic PD in terms of its clinical heterogeneity in contrast to PD associated with GBA heterozygote mutations. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 15% |
Student > Bachelor | 6 | 13% |
Other | 4 | 9% |
Researcher | 4 | 9% |
Student > Postgraduate | 2 | 4% |
Other | 6 | 13% |
Unknown | 18 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 17% |
Neuroscience | 4 | 9% |
Psychology | 4 | 9% |
Nursing and Health Professions | 3 | 6% |
Agricultural and Biological Sciences | 3 | 6% |
Other | 6 | 13% |
Unknown | 19 | 40% |