| Title |
DNA Methylation and Hydroxymethylation Levels in Relation to Two Weight Loss Strategies: Energy-Restricted Diet or Bariatric Surgery
|
|---|---|
| Published in |
Obesity Surgery, July 2015
|
| DOI | 10.1007/s11695-015-1802-8 |
| Pubmed ID | |
| Authors |
Carolina Ferreira Nicoletti, Carla Barbosa Nonino, Bruno Affonso Parenti de Oliveira, Marcela Augusta de Souza Pinhel, Maria Luisa Mansego, Fermin Ignacio Milagro, Maria Angeles Zulet, José Alfredo Martinez |
| Abstract |
Weight loss can be influenced by genetic factors and epigenetic mechanisms that participate in the regulation of body weight. This study aimed to investigate whether the weight loss induced by two different obesity treatments (energy restriction or bariatric surgery) may affect global DNA methylation (LINE-1) and hydroxymethylation profile, as well as the methylation patterns in inflammatory genes. This study encompassed women from three differents groups: 1. control group (n = 9), normal weight individuals; 2. energy restriction group (n = 22), obese patients following an energy-restricted Mediterranean-based dietary treatment (RESMENA); and 3. bariatric surgery group (n = 14), obese patients underwent a hypocaloric diet followed by bariatric surgery. Anthropometric measurements and 12-h fasting blood samples were collected before the interventions and after 6 months. Lipid and glucose biomarkers, global hydroxymethylation (by ELISA), LINE-1, SERPINE-1, and IL-6 (by MS-HRM) methylation levels were assessed in all participants. Baseline LINE-1 methylation was associated with serum glucose levels whereas baseline hydroxymethylation was associated with BMI, waist circumference, total cholesterol, and triglycerides. LINE-1 and SERPINE-1 methylation levels did not change after weight loss, whereas IL-6 methylation increased after energy restriction and decreased in the bariatric surgery group. An association between SERPINE-1 methylation and weight loss responses was found. Global DNA methylation and hydroxymethylation might be biomarkers for obesity and associated comorbidities. Depending on the obesity treatment (diet or surgery), the DNA methylation patterns behave differently. Baseline SERPINE-1 methylation may be a predictor of weight loss values after bariatric surgery. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Belgium | 1 | <1% |
| Unknown | 135 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 17% |
| Student > Ph. D. Student | 20 | 15% |
| Student > Bachelor | 16 | 12% |
| Student > Master | 15 | 11% |
| Student > Doctoral Student | 6 | 4% |
| Other | 16 | 12% |
| Unknown | 41 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 23 | 17% |
| Medicine and Dentistry | 23 | 17% |
| Agricultural and Biological Sciences | 18 | 13% |
| Nursing and Health Professions | 9 | 7% |
| Business, Management and Accounting | 2 | 1% |
| Other | 12 | 9% |
| Unknown | 50 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2022.
All research outputs
#4,209,240
of 23,257,423 outputs
Outputs from Obesity Surgery
#521
of 3,429 outputs
Outputs of similar age
#52,370
of 264,855 outputs
Outputs of similar age from Obesity Surgery
#8
of 64 outputs
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