Title |
Inhibition of Aortic Valve Calcification by Local Delivery of Zoledronic Acid—an Experimental Study
|
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Published in |
Journal of Cardiovascular Translational Research, March 2018
|
DOI | 10.1007/s12265-018-9802-4 |
Pubmed ID | |
Authors |
Andreas Synetos, Konstantinos Toutouzas, Maria Drakopoulou, Iosif Koutagiar, George Benetos, Rafail Kotronias, Nikolaos Anousakis-Vlachochristou, George Latsios, Antonis Karanasos, George Agrogiannis, Marinos Metaxas, Konstantinos Stathogiannis, Aggelos Papanikolaou, Alexandros Georgakopoulos, Nikoleta Pianou, Eleftherios Tsiamis, Efstratios Patsouris, Apostolos Papalois, Dennis Cokkinos, Constantinos Anagnostopoulos, Dimitrios Tousoulis |
Abstract |
The aim of this study was to evaluate in an experimental model of aortic valve (AV) stenosis the effectiveness of zoledronate on the inhibition of calcification. Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks. All animals underwent PET/CT at baseline and before euthanasia to assess calcification. Thereafter, the AVs of eight animals were treated with local delivery of 500 μg/l zoledronate. A placebo mixture was administered in the remaining eight animals. Standardized uptake values were corrected for blood pool activity, providing mean tissue to background ratios (TBRmean). In the zoledronate group, there was no progression of AV calcification (TBRmean 1.20 ± 0.12 vs 1.17 ± 0.78,p = 0.29), while AV calcification progressed in the placebo group (1.22 ± 0.15 vs 1.53 ± 0.23,p = 0.006). Ascending aorta (AA) calcification progressed in both zoledronate and placebo groups. Histology confirmed the results of the PET/CT. Inhibition of AV calcification by local delivery of zoledronate is feasible and effective. |
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Geographical breakdown
Country | Count | As % |
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United States | 5 | 45% |
United Kingdom | 2 | 18% |
Canada | 1 | 9% |
Belgium | 1 | 9% |
Unknown | 2 | 18% |
Demographic breakdown
Type | Count | As % |
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Scientists | 6 | 55% |
Members of the public | 3 | 27% |
Science communicators (journalists, bloggers, editors) | 1 | 9% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 25% |
Other | 2 | 10% |
Student > Master | 2 | 10% |
Researcher | 2 | 10% |
Student > Ph. D. Student | 1 | 5% |
Other | 3 | 15% |
Unknown | 5 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 30% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 15% |
Materials Science | 2 | 10% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Arts and Humanities | 1 | 5% |
Other | 1 | 5% |
Unknown | 6 | 30% |