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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase
|
|---|---|
| Published in |
Journal of Medicinal Chemistry, September 2011
|
| DOI | 10.1021/jm2006222 |
| Pubmed ID | |
| Authors |
Vito Guagnano, Pascal Furet, Carsten Spanka, Vincent Bordas, Mickaël Le Douget, Christelle Stamm, Josef Brueggen, Michael R. Jensen, Christian Schnell, Herbert Schmid, Markus Wartmann, Joerg Berghausen, Peter Drueckes, Alfred Zimmerlin, Dirksen Bussiere, Jeremy Murray, Diana Graus Porta |
| Abstract |
A novel series of N-aryl-N'-pyrimidin-4-yl ureas has been optimized to afford potent and selective inhibitors of the fibroblast growth factor receptor tyrosine kinases 1, 2, and 3 by rationally designing the substitution pattern of the aryl ring. On the basis of its in vitro profile, compound 1h (NVP-BGJ398) was selected for in vivo evaluation and showed significant antitumor activity in RT112 bladder cancer xenografts models overexpressing wild-type FGFR3. These results support the potential therapeutic use of 1h as a new anticancer agent. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Unknown | 168 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 21% |
| Researcher | 31 | 18% |
| Student > Bachelor | 15 | 9% |
| Student > Postgraduate | 12 | 7% |
| Student > Master | 12 | 7% |
| Other | 30 | 18% |
| Unknown | 35 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 34 | 20% |
| Biochemistry, Genetics and Molecular Biology | 31 | 18% |
| Medicine and Dentistry | 24 | 14% |
| Agricultural and Biological Sciences | 20 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 8% |
| Other | 13 | 8% |
| Unknown | 34 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#982,626
of 24,535,155 outputs
Outputs from Journal of Medicinal Chemistry
#199
of 22,808 outputs
Outputs of similar age
#3,970
of 134,340 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#2
of 116 outputs
Altmetric has tracked 24,535,155 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,808 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 134,340 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.