| Title |
Intraoperative Assessment of Final Margins with a Handheld Optical Imaging Probe During Breast-Conserving Surgery May Reduce the Reoperation Rate: Results of a Multicenter Study
|
|---|---|
| Published in |
Annals of Surgical Oncology, July 2015
|
| DOI | 10.1245/s10434-015-4665-2 |
| Pubmed ID | |
| Authors |
Adam M. Zysk, Kai Chen, Edward Gabrielson, Lorraine Tafra, Evelyn A. May Gonzalez, Joseph K. Canner, Eric B. Schneider, Andrew J. Cittadine, P. Scott Carney, Stephen A. Boppart, Kimiko Tsuchiya, Kristen Sawyer, Lisa K. Jacobs |
| Abstract |
A multicenter, prospective, blinded study was performed to test the feasibility of using a handheld optical imaging probe for the intraoperative assessment of final surgical margins during breast-conserving surgery (BCS) and to determine the potential impact on patient outcomes. Forty-six patients with early-stage breast cancer (one with bilateral disease) undergoing BCS at two study sites, the Johns Hopkins Hospital and Anne Arundel Medical Center, were enrolled in this study. During BCS, cavity-shaved margins were obtained and the final margins were examined ex vivo in the operating room with a probe incorporating optical coherence tomography (OCT) hardware and interferometric synthetic aperture microscopy (ISAM) image processing. Images were interpreted after BCS by three physicians blinded to final pathology-reported margin status. Individual and combined interpretations were assessed. Results were compared to conventional postoperative histopathology. A total of 2,191 images were collected and interpreted from 229 shave margin specimens. Of the eight patients (17 %) with positive margins (0 mm), which included invasive and in situ diseases, the device identified all positive margins in five (63 %) of them; reoperation could potentially have been avoided in these patients. Among patients with pathologically negative margins (>0 mm), an estimated mean additional tissue volume of 10.7 ml (approximately 1 % of overall breast volume) would have been unnecessarily removed due to false positives. Intraoperative optical imaging of specimen margins with a handheld probe potentially eliminates the majority of reoperations. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 90 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 20% |
| Student > Ph. D. Student | 17 | 19% |
| Student > Master | 10 | 11% |
| Student > Doctoral Student | 8 | 9% |
| Student > Bachelor | 8 | 9% |
| Other | 11 | 12% |
| Unknown | 19 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 26 | 29% |
| Medicine and Dentistry | 20 | 22% |
| Physics and Astronomy | 6 | 7% |
| Agricultural and Biological Sciences | 3 | 3% |
| Nursing and Health Professions | 3 | 3% |
| Other | 10 | 11% |
| Unknown | 23 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2017.
All research outputs
#2,773,920
of 22,817,213 outputs
Outputs from Annals of Surgical Oncology
#744
of 6,464 outputs
Outputs of similar age
#37,062
of 263,718 outputs
Outputs of similar age from Annals of Surgical Oncology
#11
of 126 outputs
Altmetric has tracked 22,817,213 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,464 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,718 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.