↓ Skip to main content

Effect of flunarizine on electroencephalogram recovery and brain temperature in gerbils after brain ischemia.

Overview of attention for article published in Stroke, February 1992
Altmetric Badge

Mentioned by

patent
2 patents

Citations

dimensions_citation
8 Dimensions

Readers on

mendeley
9 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Effect of flunarizine on electroencephalogram recovery and brain temperature in gerbils after brain ischemia.
Published in
Stroke, February 1992
DOI 10.1161/01.str.23.2.229
Pubmed ID
Authors

S L Cohan, D Redmond, M Chen

Abstract

This study was designed to determine whether flunarizine enhances the rate of brain recovery as measured by electroencephalography after cerebral ischemia and whether these effects are attributable to changes in brain temperature. Male gerbils (n = 81) were treated with either 10 mg/kg flunarizine or its vehicle, beta-cyclodextrin, intraperitoneally, 60 minutes before bilateral carotid occlusion of either 4 or 6 minutes' duration. The electroencephalogram was continuously recorded in the preischemic, ischemic, and postischemic stages of the experiment and rated for the time necessary for the return of 4-6, 7-10, and 11-15 Hz activity. In a second set of experiments, intracerebral temperature was monitored for 60 minutes before ischemia, during 10 minutes of carotid occlusion, and for 60 minutes after ischemia. Flunarizine pretreatment resulted in significantly more rapid return of electroencephalographic activity in each of the three frequency categories monitored when compared with those animals pretreated with vehicle alone (p less than 0.001). Flunarizine had no effect on brain temperature before, during, or up to 60 minutes after termination of ischemia. Flunarizine, which has been of efficacy in reducing neuronal death, mortality, and functional impairment when administered after ischemic insults, may have prophylactic value in accelerating brain recovery from ischemia, but does not have this effect as a result of altered brain temperature.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 33%
Student > Bachelor 1 11%
Student > Master 1 11%
Unknown 4 44%
Readers by discipline Count As %
Medicine and Dentistry 2 22%
Agricultural and Biological Sciences 1 11%
Veterinary Science and Veterinary Medicine 1 11%
Economics, Econometrics and Finance 1 11%
Neuroscience 1 11%
Other 0 0%
Unknown 3 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2000.
All research outputs
#7,568,674
of 23,083,773 outputs
Outputs from Stroke
#6,348
of 11,646 outputs
Outputs of similar age
#12,592
of 61,955 outputs
Outputs of similar age from Stroke
#3
of 14 outputs
Altmetric has tracked 23,083,773 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,646 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 61,955 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.