| Title |
Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis
|
|---|---|
| Published in |
BMC Infectious Diseases, February 2017
|
| DOI | 10.1186/s12879-017-2258-3 |
| Pubmed ID | |
| Authors |
Verónica Velasquez-Agudelo, Jaiberth Antonio Cardona-Arias |
| Abstract |
Onychomycosis is a highly prevalent disease worldwide. There is no standard test for its diagnosis, which remains costly, wasteful, and is sometimes delayed. The diagnostic tests for this disease are few and discordant. The objective was to evaluate the diagnostic validity, performance, and accuracy of culture, nail clipping with Periodic Acid-Schiff -PAS- staining (biopsy), and direct potassium hydroxide (KOH) examination for the study of onychomycosis. A systematic review was conducted via meta-analysis using 5 databases and 21 search strategies. An ex ante protocol was applied with inclusion and exclusion criteria. Quality was assessed with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool, and the sensitivity, specificity, predictive values, likelihood ratios, diagnostic odds ratios, receiver operating characteristic (ROC) curves, and proportion of correctly diagnosed patients were evaluated with the meta-analysis of studies of evaluations of diagnostic and screening tests (Meta-DiSc) and Epidat using a random effects model. The efficiency or accuracy of the three tests is influenced by the methodological quality of the studies. These values are lower for KOH and culture and higher for biopsy in moderate quality studies. The diagnostic tests evaluated in this meta-analysis independently showed acceptable validity, performance, and efficiency, with nail clipping with PAS staining outperforming the other two tests. |
Mendeley readers
The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 122 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 20 | 16% |
| Student > Bachelor | 16 | 13% |
| Other | 12 | 10% |
| Researcher | 7 | 6% |
| Student > Doctoral Student | 7 | 6% |
| Other | 29 | 24% |
| Unknown | 31 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 52 | 43% |
| Immunology and Microbiology | 7 | 6% |
| Nursing and Health Professions | 7 | 6% |
| Unspecified | 6 | 5% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Other | 14 | 11% |
| Unknown | 30 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2022.
All research outputs
#4,823,325
of 23,269,984 outputs
Outputs from BMC Infectious Diseases
#1,593
of 7,791 outputs
Outputs of similar age
#85,695
of 311,825 outputs
Outputs of similar age from BMC Infectious Diseases
#54
of 161 outputs
Altmetric has tracked 23,269,984 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,791 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one has done well, scoring higher than 79% of its peers.
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We're also able to compare this research output to 161 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.