| Title |
Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study
|
|---|---|
| Published in |
Journal of Neurology, May 2018
|
| DOI | 10.1007/s00415-018-8903-y |
| Pubmed ID | |
| Authors |
Ian Marshall, Michael J. Thrippleton, Mark E. Bastin, Daisy Mollison, David A. Dickie, Francesca M. Chappell, Scott I. K. Semple, Annette Cooper, Sue Pavitt, Gavin Giovannoni, Claudia A. M. Gandini Wheeler-Kingshott, Bhavana S. Solanky, Christopher J. Weir, Nigel Stallard, Clive Hawkins, Basil Sharrack, Jeremy Chataway, Peter Connick, Siddharthan Chandran, for the MS-SMART Trialists |
| Abstract |
Proton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with secondary progressive multiple sclerosis (SPMS). Linear modelling with respect to brain tissue type yielded metabolite levels that were significantly different in white matter lesions compared with normal-appearing white matter, suggestive of higher myelin turnover (higher choline), higher metabolic rate (higher creatine) and increased glial activity (higher myo-inositol) within the lesions. These findings suggest that the lesions have ongoing cellular activity that is not consistent with the usual assumption of 'chronic' lesions in SPMS, and may represent a target for repair therapies. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 50% |
| Spain | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Scientists | 1 | 13% |
| Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 5 | 17% |
| Student > Bachelor | 4 | 13% |
| Professor | 3 | 10% |
| Student > Ph. D. Student | 3 | 10% |
| Researcher | 3 | 10% |
| Other | 8 | 27% |
| Unknown | 4 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 27% |
| Neuroscience | 6 | 20% |
| Nursing and Health Professions | 2 | 7% |
| Psychology | 2 | 7% |
| Sports and Recreations | 2 | 7% |
| Other | 4 | 13% |
| Unknown | 6 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2018.
All research outputs
#6,603,248
of 23,760,369 outputs
Outputs from Journal of Neurology
#1,614
of 4,643 outputs
Outputs of similar age
#113,076
of 332,346 outputs
Outputs of similar age from Journal of Neurology
#28
of 72 outputs
Altmetric has tracked 23,760,369 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 4,643 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,346 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.