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Buprenorphine alleviates neuropathic pain-like behaviors in rats after spinal cord and peripheral nerve injury

Overview of attention for article published in European Journal of Pharmacology, August 2002
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Title
Buprenorphine alleviates neuropathic pain-like behaviors in rats after spinal cord and peripheral nerve injury
Published in
European Journal of Pharmacology, August 2002
DOI 10.1016/s0014-2999(02)02052-6
Pubmed ID
Authors

Poli Francois Kouya, Jing-Xia Hao, Xiao-Jun Xu

Abstract

We have studied and compared the antinociceptive and anti-hyperalgesic effect of the partial opioid receptor agonist buprenorphine in normal and neuropathic rats. In normal rats, systemic buprenorphine produced dose-dependent antinociception on the hot plate test. In rats with peripheral nerve or spinal cord injury, buprenorphine markedly alleviated neuropathic pain-related behaviors, including mechanical and cold allodynia/hyperalgesia at doses comparable to that producing antinociception. The results suggest that buprenorphine may be a useful analgesic for treating neuropathic pain and thus is an atypical opioid since morphine tends to be less potent after nerve injury.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Colombia 1 4%
Unknown 22 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 21%
Student > Postgraduate 4 17%
Student > Ph. D. Student 3 13%
Professor > Associate Professor 3 13%
Professor 2 8%
Other 6 25%
Unknown 1 4%
Readers by discipline Count As %
Medicine and Dentistry 12 50%
Agricultural and Biological Sciences 3 13%
Engineering 3 13%
Neuroscience 2 8%
Psychology 2 8%
Other 0 0%
Unknown 2 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2006.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from European Journal of Pharmacology
#2,351
of 8,584 outputs
Outputs of similar age
#16,692
of 48,162 outputs
Outputs of similar age from European Journal of Pharmacology
#15
of 49 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,584 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 48,162 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.