Title |
Buprenorphine alleviates neuropathic pain-like behaviors in rats after spinal cord and peripheral nerve injury
|
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Published in |
European Journal of Pharmacology, August 2002
|
DOI | 10.1016/s0014-2999(02)02052-6 |
Pubmed ID | |
Authors |
Poli Francois Kouya, Jing-Xia Hao, Xiao-Jun Xu |
Abstract |
We have studied and compared the antinociceptive and anti-hyperalgesic effect of the partial opioid receptor agonist buprenorphine in normal and neuropathic rats. In normal rats, systemic buprenorphine produced dose-dependent antinociception on the hot plate test. In rats with peripheral nerve or spinal cord injury, buprenorphine markedly alleviated neuropathic pain-related behaviors, including mechanical and cold allodynia/hyperalgesia at doses comparable to that producing antinociception. The results suggest that buprenorphine may be a useful analgesic for treating neuropathic pain and thus is an atypical opioid since morphine tends to be less potent after nerve injury. |
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