| Title |
Repetitive transcranial magnetic stimulation combined with cognitive training is a safe and effective modality for the treatment of Alzheimer’s disease: a randomized, double-blind study
|
|---|---|
| Published in |
Journal of Neural Transmission, October 2012
|
| DOI | 10.1007/s00702-012-0902-z |
| Pubmed ID | |
| Authors |
Jose M. Rabey, Evgenia Dobronevsky, Sergio Aichenbaum, Ofer Gonen, Revital Gendelman Marton, Michael Khaigrekht |
| Abstract |
Cortical excitability can be modulated using repetitive transcranial magnetic stimulation (rTMS). Previously, we showed that rTMS combined with cognitive training (rTMS-COG) has positive results in Alzheimer's disease (AD). The goal of this randomized double-blind, controlled study was to examine the safety and efficacy of rTMS-COG in AD. Fifteen AD patients received 1-h daily rTMS-COG or sham treatment (seven treated, eight placebo), five sessions/week for 6 weeks, followed by biweekly sessions for 3 months. The primary outcome was improvement of the cognitive score. The secondary outcome included improvement in the Clinical Global Impression of Change (CGIC) and Neuropsychiatric Inventory (NPI). There was an improvement in the average ADAS-cog score of 3.76 points after 6 weeks in the treatment group compared to 0.47 in the placebo group and 3.52 points after 4.5 months of treatment, compared to worsening of 0.38 in the placebo (P = 0.04 and P = 0.05, respectively). There was also an improvement in the average CGIC score of 3.57 (after 6 weeks) and 3.67 points (after 4.5 months), compared to 4.25 and 4.29 in the placebo group (mild worsening) (P = 0.05 and P = 0.05, respectively). NPI improved non-significantly. In summary, the NeuroAD system offers a novel, safe and effective therapy for improving cognitive function in AD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 279 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 1% |
| United Kingdom | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 274 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 55 | 20% |
| Student > Master | 40 | 14% |
| Student > Ph. D. Student | 38 | 14% |
| Student > Bachelor | 36 | 13% |
| Student > Doctoral Student | 17 | 6% |
| Other | 42 | 15% |
| Unknown | 51 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 52 | 19% |
| Medicine and Dentistry | 51 | 18% |
| Neuroscience | 48 | 17% |
| Agricultural and Biological Sciences | 13 | 5% |
| Engineering | 11 | 4% |
| Other | 38 | 14% |
| Unknown | 66 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2018.
All research outputs
#2,282,952
of 22,817,213 outputs
Outputs from Journal of Neural Transmission
#92
of 1,766 outputs
Outputs of similar age
#16,450
of 176,064 outputs
Outputs of similar age from Journal of Neural Transmission
#2
of 14 outputs
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.