| Title |
Synthesis and production of the antitumor polyketide aurovertins and structurally related compounds
|
|---|---|
| Published in |
Applied Microbiology and Biotechnology, June 2018
|
| DOI | 10.1007/s00253-018-9123-1 |
| Pubmed ID | |
| Authors |
Wei Li, Zihui Ma, Lin Chen, Wen-Bing Yin |
| Abstract |
Aurovertins belong to a family of highly reducing polyketides sharing a polyene α-pyrone-type structure. These compounds comprise aurovertin, asteltoxin, avertoxin, citreoviridin, verrucosidin, and their derivatives, which exihibit potent antitumor, antiviral, and antibacterial activities. Until now, over 40 aurovertins and structurally related compounds have been found in the fungal kingdom. Due to the unique structural feature and interesting bioactivities, significant progresses have been achieved for the structural identification, chemical synthesis, and biosynthesis of the mentioned compounds. Understanding of aurovertin biosynthetic mechanism provides a solid basis for engineering the metabolic pathway of those compounds by rational design and realizing their production in the model fungal host. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 23% |
| Researcher | 4 | 18% |
| Student > Master | 3 | 14% |
| Student > Bachelor | 3 | 14% |
| Other | 1 | 5% |
| Other | 2 | 9% |
| Unknown | 4 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 50% |
| Chemistry | 4 | 18% |
| Agricultural and Biological Sciences | 3 | 14% |
| Unknown | 4 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2018.
All research outputs
#19,611,252
of 24,119,703 outputs
Outputs from Applied Microbiology and Biotechnology
#6,478
of 8,034 outputs
Outputs of similar age
#259,194
of 334,079 outputs
Outputs of similar age from Applied Microbiology and Biotechnology
#99
of 156 outputs
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