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Pleomorphic giant cell carcinoma of the urinary bladder: an extreme form of tumour de‐differentiation

Overview of attention for article published in Histopathology, September 2015
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  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Average Attention Score compared to outputs of the same age and source

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29 Mendeley
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Title
Pleomorphic giant cell carcinoma of the urinary bladder: an extreme form of tumour de‐differentiation
Published in
Histopathology, September 2015
DOI 10.1111/his.12785
Pubmed ID
Authors

Hemamali Samaratunga, Brett Delahunt, Lars Egevad, Michael Adamson, David Hussey, Greg Malone, Kirsten Hoyle, Tim Nathan, David Kerle, Peter Ferguson, John N Nacey

Abstract

Vesical pleomorphic giant cell carcinoma (PGCC) is a variant of urothelial carcinoma (UC) characterized by highly pleomorphic tumour with giant cells. Less than 10 cases have been reported and our aim was to determine the clinical and pathological features of a series of tumours from a specialized uropathology laboratory. Thirteen cases of PGCC of the bladder were identified. There were 9 males and 4 females ranging in age from 53-92 years (mean 72 years). Associated conventional high grade UC was seen in 8 cases, while 3 cases also had micropapillary UC and 1 plasmacytoid UC. UC in situ (CIS) was present in 5 cases and occasional bizarre cells were seen in both UC and CIS. The proportion of PGCC present varied from 40% to 100% of tumour. Immunostaining performed on 10 cases showed uniform positivity for CK 8/18 and AE1/AE3, while most tumours were positive for CK7, CK20, Uroplakin III, and GATA-3. β hCG was negative. Of 10 patients with follow-up, 5 died within 1 year and 4 are alive with tumour. The association of PGCC with UC and an overlap in immunoexpression suggests that PGCC represents an extreme form of UC de-differentiation. This article is protected by copyright. All rights reserved.

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The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 5 17%
Researcher 5 17%
Student > Master 2 7%
Professor 2 7%
Lecturer 1 3%
Other 4 14%
Unknown 10 34%
Readers by discipline Count As %
Medicine and Dentistry 15 52%
Agricultural and Biological Sciences 1 3%
Unknown 13 45%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 September 2015.
All research outputs
#14,282,227
of 25,210,618 outputs
Outputs from Histopathology
#1,829
of 3,496 outputs
Outputs of similar age
#126,577
of 281,055 outputs
Outputs of similar age from Histopathology
#35
of 52 outputs
Altmetric has tracked 25,210,618 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,496 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,055 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.