Title |
Enterovirus D68 disease and molecular epidemiology in Australia
|
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Published in |
Journal of Clinical Virology, June 2015
|
DOI | 10.1016/j.jcv.2015.06.079 |
Pubmed ID | |
Authors |
Avram Levy, Jason Roberts, Jurissa Lang, Simone Tempone, Alison Kesson, Alfred Dofai, Andrew J. Daley, Bruce Thorley, David J. Speers |
Abstract |
Enterovirus D68 (EV-D68) has received considerable recent attention as a cause of widespread respiratory illness. Neurological syndromes such as acute flaccid paralysis following EV-D68 infection have also been reported in a small number of cases. To summarize the clinical and epidemiological characteristics of laboratory confirmed EV-D68 cases in Australia. We combined EV-D68 data acquired through laboratory surveillance in Western Australia with cases from national enterovirus surveillance and regional acute flaccid paralysis (AFP) surveillance. Clinical data was obtained for EV-D68 cases and capsid protein sequences were used for phylogenetic analysis. Sporadic cases of EV-D68 were recorded in Australia since 2008, with peaks in activity during 2011 and 2013. EV-D68 was primarily associated with respiratory disease, but was also detected in cerebrospinal fluid of one patient and faeces of two patients presenting with AFP. EV-D68 has been circulating in Western Australia and is likely to have also been present in the wider region for a number of years, causing primarily respiratory disease. Detection of EV-D68 in cerebrospinal fluid of one patient and in faeces of two AFP cases reinforces the association between EV-D68 and neurological disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
China | 1 | 2% |
Unknown | 42 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 23% |
Other | 5 | 11% |
Student > Master | 5 | 11% |
Student > Ph. D. Student | 4 | 9% |
Student > Bachelor | 4 | 9% |
Other | 6 | 14% |
Unknown | 10 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 23% |
Immunology and Microbiology | 7 | 16% |
Agricultural and Biological Sciences | 7 | 16% |
Biochemistry, Genetics and Molecular Biology | 3 | 7% |
Nursing and Health Professions | 2 | 5% |
Other | 2 | 5% |
Unknown | 13 | 30% |