| Title |
An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese
|
|---|---|
| Published in |
Diabetologia, May 2018
|
| DOI | 10.1007/s00125-018-4640-0 |
| Pubmed ID | |
| Authors |
Anne-Sofie Graae, Mette Hollensted, Julie T. Kloppenborg, Yuvaraj Mahendran, Theresia M. Schnurr, Emil Vincent R. Appel, Johanne Rask, Tenna R. H. Nielsen, Mia Ø. Johansen, Allan Linneberg, Marit E. Jørgensen, Niels Grarup, Haja N. Kadarmideen, Birgitte Holst, Oluf Pedersen, Jens-Christian Holm, Torben Hansen |
| Abstract |
A genetic risk score (GRS) consisting of 53 insulin resistance variants (GRS53) was recently demonstrated to associate with insulin resistance in adults. We speculated that the GRS53 might already associate with insulin resistance during childhood, and we therefore aimed to investigate this in populations of Danish children and adolescents. Furthermore, we aimed to address whether the GRS associates with components of the metabolic syndrome and altered body composition in children and adolescents. We examined a total of 689 children and adolescents who were overweight or obese and 675 children and adolescents from a population-based study. Anthropometric data, dual-energy x-ray absorptiometry scans, BP, fasting plasma glucose, fasting serum insulin and fasting plasma lipid measurements were obtained, and HOMA-IR was calculated. The GRS53 was examined for association with metabolic traits in children by linear regressions using an additive genetic model. In overweight/obese children and adolescents, the GRS53 associated with higher HOMA-IR (β = 0.109 ± 0.050 (SE); p = 2.73 × 10-2), fasting plasma glucose (β = 0.010 ± 0.005 mmol/l; p = 2.51 × 10-2) and systolic BP SD score (β = 0.026 ± 0.012; p = 3.32 × 10-2) as well as lower HDL-cholesterol (β = -0.008 ± 0.003 mmol/l; p = 1.23 × 10-3), total fat-mass percentage (β = -0.143 ± 0.054%; p = 9.15 × 10-3) and fat-mass percentage in the legs (β = -0.197 ± 0.055%; p = 4.09 × 10-4). In the population-based sample of children, the GRS53 only associated with lower HDL-cholesterol concentrations (β = -0.007 ± 0.003 mmol/l; p = 1.79 × 10-2). An adult-based GRS comprising 53 insulin resistance susceptibility SNPs associates with insulin resistance, markers of the metabolic syndrome and altered fat distribution in a sample of Danish children and adolescents who were overweight or obese. |
X Demographics
The data shown below were collected from the profiles of 27 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 11% |
| Canada | 2 | 7% |
| United States | 2 | 7% |
| Denmark | 1 | 4% |
| Saudi Arabia | 1 | 4% |
| Mexico | 1 | 4% |
| Greece | 1 | 4% |
| Finland | 1 | 4% |
| Spain | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 12 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 67% |
| Scientists | 7 | 26% |
| Practitioners (doctors, other healthcare professionals) | 2 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 15% |
| Student > Master | 5 | 10% |
| Student > Ph. D. Student | 5 | 10% |
| Other | 4 | 8% |
| Researcher | 3 | 6% |
| Other | 6 | 13% |
| Unknown | 18 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 23% |
| Nursing and Health Professions | 5 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 6% |
| Veterinary Science and Veterinary Medicine | 1 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 6 | 13% |
| Unknown | 21 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2019.
All research outputs
#1,354,954
of 25,223,158 outputs
Outputs from Diabetologia
#736
of 5,331 outputs
Outputs of similar age
#28,850
of 337,838 outputs
Outputs of similar age from Diabetologia
#22
of 61 outputs
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So far Altmetric has tracked 5,331 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has done well, scoring higher than 86% of its peers.
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We're also able to compare this research output to 61 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.