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A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae

Overview of attention for article published in Nature Communications, July 2015
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

news
4 news outlets
blogs
1 blog
twitter
21 X users

Citations

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108 Dimensions

Readers on

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87 Mendeley
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Title
A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae
Published in
Nature Communications, July 2015
DOI 10.1038/ncomms8828
Pubmed ID
Authors

John M. Atack, Yogitha N. Srikhanta, Kate L. Fox, Joseph A. Jurcisek, Kenneth L. Brockman, Tyson A. Clark, Matthew Boitano, Peter M. Power, Freda E.-C. Jen, Alastair G. McEwan, Sean M. Grimmond, Arnold L. Smith, Stephen J. Barenkamp, Jonas Korlach, Lauren O. Bakaletz, Michael P. Jennings

Abstract

Non-typeable Haemophilus influenzae contains an N(6)-adenine DNA-methyltransferase (ModA) that is subject to phase-variable expression (random ON/OFF switching). Five modA alleles, modA2, modA4, modA5, modA9 and modA10, account for over two-thirds of clinical otitis media isolates surveyed. Here, we use single molecule, real-time (SMRT) methylome analysis to identify the DNA-recognition motifs for all five of these modA alleles. Phase variation of these alleles regulates multiple proteins including vaccine candidates, and key virulence phenotypes such as antibiotic resistance (modA2, modA5, modA10), biofilm formation (modA2) and immunoevasion (modA4). Analyses of a modA2 strain in the chinchilla model of otitis media show a clear selection for ON switching of modA2 in the middle ear. Our results indicate that a biphasic epigenetic switch can control bacterial virulence, immunoevasion and niche adaptation in an animal model system.

X Demographics

X Demographics

The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
United States 1 1%
Colombia 1 1%
Unknown 84 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 25%
Student > Master 15 17%
Researcher 10 11%
Student > Bachelor 5 6%
Student > Doctoral Student 4 5%
Other 14 16%
Unknown 17 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 33%
Biochemistry, Genetics and Molecular Biology 13 15%
Medicine and Dentistry 9 10%
Immunology and Microbiology 8 9%
Nursing and Health Professions 2 2%
Other 7 8%
Unknown 19 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2016.
All research outputs
#774,430
of 23,322,258 outputs
Outputs from Nature Communications
#13,010
of 48,233 outputs
Outputs of similar age
#10,181
of 264,445 outputs
Outputs of similar age from Nature Communications
#169
of 796 outputs
Altmetric has tracked 23,322,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 48,233 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 56.1. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,445 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 796 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.