| Title |
Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex
|
|---|---|
| Published in |
Molecular Neurobiology, June 2018
|
| DOI | 10.1007/s12035-018-1143-4 |
| Pubmed ID | |
| Authors |
Amanda J. Sales, Manoela V. Fogaça, Ariandra G. Sartim, Vitor S. Pereira, Gregers Wegener, Francisco S. Guimarães, Sâmia R. L. Joca |
| Abstract |
Currently available antidepressants have a substantial time lag to induce therapeutic response and a relatively low efficacy. The development of drugs that addresses these limitations is critical to improving public health. Cannabidiol (CBD), a non-psychotomimetic component of Cannabis sativa, is a promising compound since it shows large-spectrum therapeutic potential in preclinical models and humans. However, its antidepressant properties have not been completely investigated. Therefore, the aims of this study were to investigate in male rodents (i) whether CBD could induce rapid and sustained antidepressant-like effects after a single administration and (ii) whether such effects could be related to changes in synaptic proteins/function. Results showed that a single dose of CBD dose-dependently induced antidepressant-like effect (7-30 mg/kg) in Swiss mice submitted to the forced swim test (FST), 30 min (acute) or 7 days (sustained) following treatment. Similar effects were observed in the Flinders Sensitive and Flinders Resistant Line (FSL/FRL) rats and the learned helplessness (LH) paradigm using Wistar rats. The acute antidepressant effects (30 min) were associated with increased expression of synaptophysin and PSD95 in the medial prefrontal cortex (mPFC) and elevated BDNF levels in both mPFC and hippocampus (HPC). CBD also increased spine density in the mPFC after 30 min, but not 7 days later. Intracerebroventricular injection of the TrkB antagonist, K252a (0.05 nmol/μL), or the mTOR inhibitor, rapamycin (1 nmol/μL), abolished the behavioral effects of CBD. These results indicate that CBD induces fast and sustained antidepressant-like effect in distinct animal models relevant for depression. These effects may be related to rapid changes in synaptic plasticity in the mPFC through activation of the BDNF-TrkB signaling pathway. The data support a promising therapeutic profile for CBD as a new fast-acting antidepressant drug. |
X Demographics
The data shown below were collected from the profiles of 187 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 51 | 27% |
| Canada | 22 | 12% |
| United Kingdom | 7 | 4% |
| Chile | 4 | 2% |
| Colombia | 3 | 2% |
| Australia | 3 | 2% |
| Spain | 3 | 2% |
| Ireland | 2 | 1% |
| Mexico | 2 | 1% |
| Other | 9 | 5% |
| Unknown | 81 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 159 | 85% |
| Practitioners (doctors, other healthcare professionals) | 20 | 11% |
| Scientists | 4 | 2% |
| Science communicators (journalists, bloggers, editors) | 3 | 2% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 272 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 272 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 38 | 14% |
| Researcher | 33 | 12% |
| Student > Ph. D. Student | 32 | 12% |
| Student > Master | 23 | 8% |
| Other | 16 | 6% |
| Other | 38 | 14% |
| Unknown | 92 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 39 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 36 | 13% |
| Agricultural and Biological Sciences | 28 | 10% |
| Medicine and Dentistry | 19 | 7% |
| Biochemistry, Genetics and Molecular Biology | 14 | 5% |
| Other | 30 | 11% |
| Unknown | 106 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 299. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2023.
All research outputs
#118,286
of 25,795,662 outputs
Outputs from Molecular Neurobiology
#5
of 4,017 outputs
Outputs of similar age
#2,610
of 344,086 outputs
Outputs of similar age from Molecular Neurobiology
#1
of 118 outputs
Altmetric has tracked 25,795,662 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,017 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done particularly well, scoring higher than 99% of its peers.
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