| Title |
The selective serotonin reuptake inhibitor fluoxetine increases spontaneous afferent firing, but not mechanonociceptive sensitization, in octopus
|
|---|---|
| Published in |
Invertebrate Neuroscience, October 2017
|
| DOI | 10.1007/s10158-017-0203-1 |
| Pubmed ID | |
| Authors |
Paul V. Perez, Hanna M. Butler-Struben, Robyn J. Crook |
| Abstract |
Serotonin is a widely studied modulator of neural plasticity. Here we investigate the effect of fluoxetine, a selective serotonin reuptake inhibitor, on short-term, peripheral nociceptive plasticity in the neurologically complex invertebrate, octopus. After crush injury to isolated mantle (body wall) tissue, application of 10 nM fluoxetine increased spontaneous firing in crushed preparations, but had a minimal effect on mechanosensory sensitization. Effects largely did not persist after washout. We suggest that transiently elevated, endogenous serotonin may help promote initiation of longer-term plasticity of nociceptive afferents and drive immediate and spontaneous behaviors aimed at protecting wounds and escaping dangerous situations. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Guinea-Bissau | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 9 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 33% |
| Student > Ph. D. Student | 2 | 22% |
| Other | 1 | 11% |
| Student > Master | 1 | 11% |
| Researcher | 1 | 11% |
| Other | 0 | 0% |
| Unknown | 1 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 33% |
| Neuroscience | 3 | 33% |
| Psychology | 1 | 11% |
| Veterinary Science and Veterinary Medicine | 1 | 11% |
| Unknown | 1 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2018.
All research outputs
#18,637,483
of 23,088,369 outputs
Outputs from Invertebrate Neuroscience
#59
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Outputs of similar age
#248,245
of 324,212 outputs
Outputs of similar age from Invertebrate Neuroscience
#1
of 1 outputs
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