Title |
Making inroads into improving treatment of bacterial vaginosis – striving for long-term cure
|
---|---|
Published in |
BMC Infectious Diseases, July 2015
|
DOI | 10.1186/s12879-015-1027-4 |
Pubmed ID | |
Authors |
Catriona S. Bradshaw, Rebecca M. Brotman |
Abstract |
Bacterial vaginosis (BV) is one of the great enigmas in women's health, a common condition of unknown aetiology, which is associated with significant morbidity and unacceptably high recurrence rates. While it remains unclear whether BV recurrence is predominantly due to failure of current antibiotic regimens to eradicate BV-associated bacteria (BVAB) and biofilm, a failure of some women to re-establish a resilient Lactobacillus-dominant vaginal microbiota, reinfection from sexual partners, or a combination of these factors, it is inherently challenging to make significant inroads towards this goal. In this review, we will outline why BV is such a clinical and epidemiologic conundrum, and focus on several key approaches that we believe merit discussion and clinical research, including strategies to: i) prevent reinfection (partner treatment trials), ii) boost favourable vaginal Lactobacillus species and promote a Lactobacillus-dominant vaginal microbiome (hormonal contraceptive and probiotic trials) and iii) disrupt vaginal BV-associated biofilm. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Norway | 1 | 14% |
Brazil | 1 | 14% |
United States | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Scientists | 1 | 14% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 183 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 26 | 14% |
Student > Bachelor | 22 | 12% |
Student > Ph. D. Student | 19 | 10% |
Other | 17 | 9% |
Researcher | 17 | 9% |
Other | 34 | 18% |
Unknown | 49 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 41 | 22% |
Biochemistry, Genetics and Molecular Biology | 18 | 10% |
Nursing and Health Professions | 14 | 8% |
Agricultural and Biological Sciences | 14 | 8% |
Immunology and Microbiology | 13 | 7% |
Other | 31 | 17% |
Unknown | 53 | 29% |