Title |
Core‐Cone Structured Monodispersed Mesoporous Silica Nanoparticles with Ultra‐large Cavity for Protein Delivery
|
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Published in |
Small, October 2015
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DOI | 10.1002/smll.201501449 |
Pubmed ID | |
Authors |
Chun Xu, Meihua Yu, Owen Noonan, Jun Zhang, Hao Song, Hongwei Zhang, Chang Lei, Yuting Niu, Xiaodan Huang, Yannan Yang, Chengzhong Yu |
Abstract |
A new type of monodispersed mesoporous silica nanoparticles with a core-cone structure (MSN-CC) has been synthesized. The large cone-shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN-CC has a large pore size of 45 nm and a high pore volume of 2.59 cm(3) g(-1) . MSN-CC demonstrates a high loading capacity of large proteins and successfully delivers active β-galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 83 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 24% |
Student > Master | 12 | 14% |
Student > Bachelor | 7 | 8% |
Professor > Associate Professor | 5 | 6% |
Researcher | 4 | 5% |
Other | 12 | 14% |
Unknown | 23 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 23 | 28% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
Chemical Engineering | 5 | 6% |
Materials Science | 5 | 6% |
Agricultural and Biological Sciences | 4 | 5% |
Other | 8 | 10% |
Unknown | 33 | 40% |