Title |
Recommendations for the treatment of Crohn's disease with tumor necrosis factor antagonists: An expert consensus report
|
---|---|
Published in |
Inflammatory Bowel Diseases, October 2011
|
DOI | 10.1002/ibd.21870 |
Pubmed ID | |
Authors |
Brian G. Feagan, Marc Lémann, Ragnar Befrits, William Connell, Geert D'Haens, Subrata Ghosh, Pierre Michetti, Thomas Ochsenkühn, Remo Panaccione, Stefan Schreiber, Mark Silverberg, Dario Sorrentino, C. Janneke van der Woude, Severine Vermeire, Paul Rutgeerts |
Abstract |
Symptom relief is the traditional treatment goal in Crohn's disease (CD). New goals including mucosal healing and bowel preservation are now achievable with tumor necrosis factor (TNF) antagonists. Infliximab and adalimumab are approved as second-line treatments for severe, active CD. Certolizumab pegol is approved only in the U.S. and Switzerland as second-line treatment for moderate-to-severe, active CD. Data from trials of infliximab suggest that high-risk patients and patients with active inflammation (CRP elevation and/or ileocolonic ulcers) may benefit from earlier use of this drug. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
United States | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 79 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 23% |
Other | 13 | 16% |
Student > Ph. D. Student | 9 | 11% |
Student > Postgraduate | 9 | 11% |
Student > Master | 7 | 8% |
Other | 16 | 19% |
Unknown | 10 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 43 | 52% |
Agricultural and Biological Sciences | 9 | 11% |
Computer Science | 2 | 2% |
Business, Management and Accounting | 2 | 2% |
Nursing and Health Professions | 2 | 2% |
Other | 13 | 16% |
Unknown | 12 | 14% |