| Title |
Four-year effects of exercise on fatigue and physical activity in patients with cancer
|
|---|---|
| Published in |
BMC Medicine, June 2018
|
| DOI | 10.1186/s12916-018-1075-x |
| Pubmed ID | |
| Authors |
Lenja Witlox, Anouk E. Hiensch, Miranda J. Velthuis, Charlotte N. Steins Bisschop, Maartje Los, Frans L. G. Erdkamp, Haiko J. Bloemendal, Marlies Verhaar, Daan ten Bokkel Huinink, Elsken van der Wall, Petra H. M. Peeters, Anne M. May |
| Abstract |
In the earlier randomized controlled Physical Activity during Cancer Treatment (PACT) study, we found beneficial effects of an 18-week supervised exercise program on fatigue in patients with newly diagnosed breast or colon cancer undergoing adjuvant treatment. The present study assessed long-term effects of the exercise program on levels of fatigue and physical activity 4 years after participation in the PACT study. The original study was a two-armed, multicenter randomized controlled trial comparing an 18-week supervised exercise program to usual care among 204 breast cancer patients and 33 colon cancer patients undergoing adjuvant treatment. Of the 237 PACT participants, 197 participants were eligible and approached to participate in the 4-year post-baseline measurements, and 128 patients responded. We assessed fatigue and physical activity levels at 4 years post-baseline and compared this to levels at baseline, post-intervention (18 weeks post-baseline), and at 36 weeks post-baseline. Intention-to-treat mixed linear effects model analyses showed that cancer patients in the intervention group reported significantly higher moderate-to-vigorous total physical activity levels (141.46 min/week (95% confidence interval (CI) 1.31, 281.61, effect size (ES) = 0.22) after 4 years compared to the usual care group. Furthermore, cancer patients in the intervention group tended to experience less physical fatigue at 4 years post-baseline compared to the usual care group (- 1.13, 95% CI -2.45, 0.20, ES = 0.22), although the result was not statistically significant. Patients with breast or colon cancer who participated in the 18-week exercise intervention showed significant higher levels of moderate-to-vigorous total physical activity levels and a tendency towards lower physical fatigue levels 4 years post-baseline. Our result indicate that exercising during chemotherapy is a promising strategy for minimizing treatment-related side effects, both short and long term. Current Controlled Trials ISRCTN43801571 , Dutch Trial Register NTR2138 . Trial registered on 9 December 2009. |
X Demographics
The data shown below were collected from the profiles of 123 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 27 | 22% |
| Australia | 11 | 9% |
| United States | 10 | 8% |
| Canada | 8 | 7% |
| Ireland | 5 | 4% |
| Netherlands | 3 | 2% |
| Luxembourg | 2 | 2% |
| Brazil | 2 | 2% |
| Indonesia | 2 | 2% |
| Other | 10 | 8% |
| Unknown | 43 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 69 | 56% |
| Scientists | 34 | 28% |
| Practitioners (doctors, other healthcare professionals) | 17 | 14% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 234 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 234 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 47 | 20% |
| Student > Master | 35 | 15% |
| Student > Ph. D. Student | 22 | 9% |
| Researcher | 16 | 7% |
| Student > Doctoral Student | 11 | 5% |
| Other | 29 | 12% |
| Unknown | 74 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 51 | 22% |
| Medicine and Dentistry | 32 | 14% |
| Sports and Recreations | 32 | 14% |
| Psychology | 8 | 3% |
| Biochemistry, Genetics and Molecular Biology | 5 | 2% |
| Other | 16 | 7% |
| Unknown | 90 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 82. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2019.
All research outputs
#505,179
of 24,942,536 outputs
Outputs from BMC Medicine
#382
of 3,897 outputs
Outputs of similar age
#11,354
of 335,187 outputs
Outputs of similar age from BMC Medicine
#13
of 58 outputs
Altmetric has tracked 24,942,536 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,897 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 45.2. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,187 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.