Title |
Posterior Fossa Syndrome in an Adult Patient Following Surgical Evacuation of an Intracerebellar Haematoma
|
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Published in |
The Cerebellum, October 2011
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DOI | 10.1007/s12311-011-0322-x |
Pubmed ID | |
Authors |
Hyo Jung De Smet, Peter Mariën |
Abstract |
The posterior fossa syndrome (PFS) consists of transient cerebellar mutism, cognitive symptoms and neurobehavioural abnormalities that typically develop in children following posterior fossa tumour resection. Although PFS has been documented in more than 350 paediatric cases, reports of adult patients with a vascular aetiology are extremely rare. In addition, the pathophysiological substrate of the syndrome remains unclear. We report an adult patient with PFS after surgical evacuation of a cerebellar bleeding. After 45 days of (akinetic) mutism, the patient's cognitive and behavioural profile closely resembled the "cerebellar cognitive-affective syndrome". A quantified SPECT study showed perfusional deficits in the anatomoclinically suspected supratentorial areas, subserving language dynamics, executive functioning, spatial cognition and affective regulation. We hypothesize that cerebello-cerebral diaschisis might be an important pathophysiological mechanism underlying akinetic mutism, cognitive deficits and behavioural-affective changes in adult patients with PFS. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 2% |
Unknown | 47 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 13% |
Student > Doctoral Student | 6 | 13% |
Other | 4 | 8% |
Student > Postgraduate | 4 | 8% |
Student > Ph. D. Student | 4 | 8% |
Other | 10 | 21% |
Unknown | 14 | 29% |
Readers by discipline | Count | As % |
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Psychology | 11 | 23% |
Neuroscience | 9 | 19% |
Medicine and Dentistry | 8 | 17% |
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Nursing and Health Professions | 2 | 4% |
Other | 2 | 4% |
Unknown | 14 | 29% |