| Title |
Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2
|
|---|---|
| Published in |
Neurochemical Research, June 2015
|
| DOI | 10.1007/s11064-015-1629-7 |
| Pubmed ID | |
| Authors |
Yang Li, Ou Lv, Fenggang Zhou, Qingsong Li, Zhichao Wu, Yongri Zheng |
| Abstract |
Linalool, a natural compound of the essential oils, has been reported to have anti-inflammatory effects. This study aimed to investigate the anti-inflammatory effects and mechanism of linalool in LPS-stimulated BV2 microglia cells. BV2 microglia cells were stimulated with LPS in the presence or absence of linalool. The production of inflammatory mediators TNF-α, IL-1β, NO, and PGE2 as well as Nrf2, HO-1 expression were detected. Our results showed that linalool inhibited LPS-induced TNF-α, IL-1β, NO, and PGE2 production in a dose-dependent manner. Linalool also inhibited LPS-induced NF-κB activation. Treatment of linalool induced nuclear translocation of Nrf2 and expression of HO-1. In addition, our results showed that the anti-inflammatory effect of linalool was attenuated by transfection with Nrf2 siRNA. In conclusion, these results suggested that linalool inhibits LPS-induced inflammation in BV2 microglia cells by activating Nrf2/HO-1 signaling pathway. |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 66 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 21% |
| Student > Master | 8 | 12% |
| Student > Doctoral Student | 5 | 8% |
| Student > Bachelor | 5 | 8% |
| Researcher | 5 | 8% |
| Other | 13 | 20% |
| Unknown | 16 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 14% |
| Agricultural and Biological Sciences | 9 | 14% |
| Biochemistry, Genetics and Molecular Biology | 8 | 12% |
| Chemistry | 6 | 9% |
| Materials Science | 3 | 5% |
| Other | 8 | 12% |
| Unknown | 23 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2015.
All research outputs
#20,284,384
of 22,818,766 outputs
Outputs from Neurochemical Research
#1,693
of 2,097 outputs
Outputs of similar age
#223,095
of 267,021 outputs
Outputs of similar age from Neurochemical Research
#22
of 34 outputs
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