| Title |
Inflammation in Alzheimer’s Disease and Molecular Genetics: Recent Update
|
|---|---|
| Published in |
Archivum Immunologiae et Therapiae Experimentalis, August 2015
|
| DOI | 10.1007/s00005-015-0351-0 |
| Pubmed ID | |
| Authors |
Zhi-Gang Zhang, Yan Li, Cheung Toa Ng, You-Qiang Song |
| Abstract |
Alzheimer's disease (AD) is a complex age-related neurodegenerative disorder of the central nervous system. Since the first description of AD in 1907, many hypotheses have been established to explain its causes. The inflammation theory is one of them. Pathological and biochemical studies of brains from AD individuals have provided solid evidence of the activation of inflammatory pathways. Furthermore, people with long-term medication of anti-inflammatory drugs have shown a reduced risk to develop the disease. After three decades of genetic study in AD, dozens of loci harboring genetic variants influencing inflammatory pathways in AD patients has been identified through genome-wide association studies (GWAS). The most well-known GWAS risk factor that is responsible for immune response and inflammation in AD development should be APOE ε4 allele. However, a growing number of other GWAS risk AD candidate genes in inflammation have recently been discovered. In the present study, we try to review the inflammation in AD and immunity-associated GWAS risk genes like HLA-DRB5/DRB1, INPP5D, MEF2C, CR1, CLU and TREM2. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| United Kingdom | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
| Scientists | 1 | 33% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 126 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 17% |
| Student > Master | 22 | 17% |
| Researcher | 19 | 15% |
| Student > Bachelor | 11 | 9% |
| Student > Postgraduate | 9 | 7% |
| Other | 21 | 16% |
| Unknown | 25 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 31 | 24% |
| Biochemistry, Genetics and Molecular Biology | 19 | 15% |
| Agricultural and Biological Sciences | 15 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 6% |
| Psychology | 8 | 6% |
| Other | 17 | 13% |
| Unknown | 31 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2016.
All research outputs
#2,704,248
of 22,818,766 outputs
Outputs from Archivum Immunologiae et Therapiae Experimentalis
#25
of 385 outputs
Outputs of similar age
#36,263
of 264,249 outputs
Outputs of similar age from Archivum Immunologiae et Therapiae Experimentalis
#2
of 13 outputs
Altmetric has tracked 22,818,766 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 385 research outputs from this source. They receive a mean Attention Score of 4.0. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,249 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.