Title |
From mice to humans: developments in cancer immunoediting
|
---|---|
Published in |
Journal of Clinical Investigation, August 2015
|
DOI | 10.1172/jci80004 |
Pubmed ID | |
Authors |
Michele W.L. Teng, Jerome Galon, Wolf-Herman Fridman, Mark J. Smyth |
Abstract |
Cancer immunoediting explains the dual role by which the immune system can both suppress and/or promote tumor growth. Although cancer immunoediting was first demonstrated using mouse models of cancer, strong evidence that it occurs in human cancers is now accumulating. In particular, the importance of CD8+ T cells in cancer immunoediting has been shown, and more broadly in those tumors with an adaptive immune resistance phenotype. This Review describes the characteristics of the adaptive immune resistance tumor microenvironment and discusses data obtained in mouse and human settings. The role of other immune cells and factors influencing the effector function of tumor-specific CD8+ T cells is covered. We also discuss the temporal occurrence of cancer immunoediting in metastases and whether it differs from immunoediting in the primary tumor of origin. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | <1% |
India | 1 | <1% |
United Kingdom | 1 | <1% |
Belgium | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 409 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 66 | 16% |
Student > Ph. D. Student | 65 | 16% |
Researcher | 55 | 13% |
Student > Bachelor | 46 | 11% |
Student > Doctoral Student | 25 | 6% |
Other | 53 | 13% |
Unknown | 104 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 80 | 19% |
Immunology and Microbiology | 61 | 15% |
Medicine and Dentistry | 59 | 14% |
Agricultural and Biological Sciences | 52 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 19 | 5% |
Other | 28 | 7% |
Unknown | 115 | 28% |