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Circulating lymphocyte and T memory subsets in glucocorticosteroid versus IVIG treated patients with CIDP

Overview of attention for article published in Journal of Neuroimmunology, April 2015
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Title
Circulating lymphocyte and T memory subsets in glucocorticosteroid versus IVIG treated patients with CIDP
Published in
Journal of Neuroimmunology, April 2015
DOI 10.1016/j.jneuroim.2015.03.023
Pubmed ID
Authors

Juliane Klehmet, Max Staudt, Lena Ulm, Nadine Unterwalder, Andreas Meisel, Christian Meisel

Abstract

The present study compared lymphocyte and T memory subsets in currently untreated patients with chronic inflammatory demyelinating polyneuropathy (CIDP) to glucocorticosteroid (GS) and intravenous immunoglobulin (IVIG) treated patients. Peripheral blood from 48 CIDP patients (21 untreated who were either treatment naïve or without treatment during the last 3months, 17 IVIG and 10 GS treatment) and from 12 age-matched controls was evaluated using flow cytometric analysis. Our data demonstrate that long-term GS treatment is associated with reduced frequencies of total CD4+ T cells, CD4+ memory subsets and NK cells while long-term IVIG treatment is associated with alterations of the CD8+ memory compartment. Reduction of CD4+ naïve T cell counts may explain the observation that GS treatment induces prolonged clinical remission compared to IVIG treatment.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 20%
Student > Ph. D. Student 7 16%
Student > Bachelor 5 11%
Student > Master 5 11%
Student > Doctoral Student 3 7%
Other 7 16%
Unknown 8 18%
Readers by discipline Count As %
Medicine and Dentistry 13 30%
Neuroscience 6 14%
Agricultural and Biological Sciences 5 11%
Psychology 3 7%
Immunology and Microbiology 2 5%
Other 5 11%
Unknown 10 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2015.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Journal of Neuroimmunology
#2,642
of 3,012 outputs
Outputs of similar age
#241,151
of 279,987 outputs
Outputs of similar age from Journal of Neuroimmunology
#43
of 54 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,012 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.