| Title |
Cognitive impairment and associated loss in brain white microstructure in aircrew members exposed to engine oil fumes
|
|---|---|
| Published in |
Brain Imaging and Behavior, June 2015
|
| DOI | 10.1007/s11682-015-9395-3 |
| Pubmed ID | |
| Authors |
Liesbeth Reneman, Sanne B. Schagen, Michel Mulder, Henri J. Mutsaerts, Gerard Hageman, Michiel B. de Ruiter |
| Abstract |
Cabin air in airplanes can be contaminated with engine oil contaminants. These contaminations may contain organophosphates (OPs) which are known neurotoxins to brain white matter. However, it is currently unknown if brain white matter in aircrew is affected. We investigated whether we could objectify cognitive complaints in aircrew and whether we could find a neurobiological substrate for their complaints. After medical ethical approval from the local institutional review board, informed consent was obtained from 12 aircrew (2 females, on average aged 44.4 years, 8,130 flying hours) with cognitive complaints and 11 well matched control subjects (2 females, 43.4 years, 233 flying hours). Depressive symptoms and self-reported cognitive symptoms were assessed, in addition to a neuropsychological test battery. State of the art Magnetic Resonance Imaging (MRI) techniques were administered that assess structural and functional changes, with a focus on white matter integrity. In aircrew we found significantly more self-reported cognitive complaints and depressive symptoms, and a higher number of tests scored in the impaired range compared to the control group. We observed small clusters in the brain in which white matter microstructure was affected. Also, we observed higher cerebral perfusion values in the left occipital cortex, and reduced brain activation on a functional MRI executive function task. The extent of cognitive impairment was strongly associated with white matter integrity, but extent of estimated number of flight hours was not associated with cognitive impairment nor with reductions in white matter microstructure. Defects in brain white matter microstructure and cerebral perfusion are potential neurobiological substrates for cognitive impairments and mood deficits reported in aircrew. |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 81 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 17% |
| Researcher | 14 | 17% |
| Student > Master | 10 | 12% |
| Student > Bachelor | 5 | 6% |
| Professor > Associate Professor | 4 | 5% |
| Other | 13 | 16% |
| Unknown | 21 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 12 | 15% |
| Medicine and Dentistry | 9 | 11% |
| Neuroscience | 9 | 11% |
| Nursing and Health Professions | 3 | 4% |
| Chemistry | 3 | 4% |
| Other | 18 | 22% |
| Unknown | 27 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2018.
All research outputs
#6,046,475
of 22,821,814 outputs
Outputs from Brain Imaging and Behavior
#321
of 1,155 outputs
Outputs of similar age
#70,018
of 264,842 outputs
Outputs of similar age from Brain Imaging and Behavior
#10
of 31 outputs
Altmetric has tracked 22,821,814 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,155 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,842 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.