Title |
Coaxial Electrospray Ionization for the Study of Rapid In-source Chemistry
|
---|---|
Published in |
Journal of the American Society for Mass Spectrometry, June 2018
|
DOI | 10.1007/s13361-018-2004-0 |
Pubmed ID | |
Authors |
Brynn N. Sundberg, Anthony F. Lagalante |
Abstract |
Coaxial electrospray has been used effectively for several dual-emitter applications, but has not been utilized for the study of rapid in-source chemistry. In this paper, we report the fabrication of a coaxial, micro-volume dual-emitter through the modification of a manufacturer's standard electrospray probe. This modification creates rapid mixing inside the Taylor cone and the ability to manipulate fast reactions using a variety of solvents and analytes. We demonstrate its potential as a low-cost, dual-emitter assembly for diverse applications through three examples: relative ionization in a biphasic electrospray, hydrogen-deuterium exchange, and protein supercharging. Graphical Abstract. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 3 | 21% |
Professor | 2 | 14% |
Researcher | 2 | 14% |
Student > Ph. D. Student | 2 | 14% |
Student > Doctoral Student | 1 | 7% |
Other | 0 | 0% |
Unknown | 4 | 29% |
Readers by discipline | Count | As % |
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Chemistry | 5 | 36% |
Engineering | 3 | 21% |
Earth and Planetary Sciences | 1 | 7% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Unknown | 4 | 29% |