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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CFH Variants Affect Structural and Functional Brain Changes and Genetic Risk of Alzheimer’s Disease
|
|---|---|
| Published in |
Neuropsychopharmacology, August 2015
|
| DOI | 10.1038/npp.2015.232 |
| Pubmed ID | |
| Authors |
Deng-Feng Zhang, Jin Li, Huan Wu, Yue Cui, Rui Bi, He-Jiang Zhou, Hui-Zhen Wang, Chen Zhang, Dong Wang, Qing-Peng Kong, Tao Li, Yiru Fang, Tianzi Jiang, Yong-Gang Yao |
| Abstract |
The immune response is highly active in Alzheimer's disease (AD). Identification of genetic risk contributed by immune genes to AD may provide essential insight for the prognosis, diagnosis, and treatment of this neurodegenerative disease. In this study, we performed a genetic screening for AD-related top immune genes identified in Europeans in a Chinese cohort, followed by a multiple-stage study focusing on Complement Factor H (CFH) gene. Effects of the risk SNPs on AD-related neuroimaging endophenotypes were evaluated through Magnetic Resonance Imaging (MRI) scan, and the effects on AD cerebrospinal fluid biomarkers (CSF) and CFH expression changes were measured in aged and AD brain tissues and AD cellular models. Our results showed that the AD-associated top immune genes reported in Europeans (CR1, CD33, CLU and TREML2) have weak effects in Chinese, whilst CFH showed strong effects. In particular, rs1061170 (Pmeta=4.0 × 10(-4)) and rs800292 (Pmeta=1.3 × 10(-5)) showed robust associations with AD, which were confirmed in multiple world-wide sample sets (4317 cases and 16795 controls). Rs1061170 (P=2.5 × 10(-3)) and rs800292 (P=4.7 × 10(-4)) risk-allele carriers have an increased entorhinal thickness in their young age and a higher atrophy rate as the disease progress. Rs800292 risk-allele carriers have higher CSF tau and Aβ levels and severe cognitive decline. CFH expression level, which was affected by the risk-alleles, was increased in AD brains and cellular models. These comprehensive analyses suggested that CFH is an important immune factor in AD and affects multiple pathological changes in early life and during disease progress.Neuropsychopharmacology accepted article preview online, 05 August 2015. doi:10.1038/npp.2015.232. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 83 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 17% |
| Student > Master | 13 | 16% |
| Researcher | 10 | 12% |
| Student > Bachelor | 8 | 10% |
| Other | 7 | 8% |
| Other | 11 | 13% |
| Unknown | 20 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 15 | 18% |
| Neuroscience | 12 | 14% |
| Agricultural and Biological Sciences | 6 | 7% |
| Psychology | 6 | 7% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Other | 14 | 17% |
| Unknown | 26 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2015.
All research outputs
#1,444,156
of 22,821,814 outputs
Outputs from Neuropsychopharmacology
#653
of 4,111 outputs
Outputs of similar age
#20,136
of 264,147 outputs
Outputs of similar age from Neuropsychopharmacology
#18
of 98 outputs
Altmetric has tracked 22,821,814 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,111 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.1. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,147 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.