| Title |
Utilizing an Ingestible Biosensor to Assess Real-Time Medication Adherence
|
|---|---|
| Published in |
Journal of Medical Toxicology, August 2015
|
| DOI | 10.1007/s13181-015-0494-8 |
| Pubmed ID | |
| Authors |
Peter R. Chai, Jose Castillo-Mancilla, Eric Buffkin, Chad Darling, Rochelle K. Rosen, Keith J. Horvath, Edwin D. Boudreaux, Gregory K. Robbins, Patricia L. Hibberd, Edward W. Boyer |
| Abstract |
Medication adherence monitoring has relied largely on indirect measures of pill ingestion including patient self-report, pharmacy refills, electronically triggered pill bottles, and pill counts. Our objective is to describe an ingestible biosensor system comprising a radio-frequency identification (RFID)-tagged gelatin capsule. Once the capsule dissolves in the stomach, the RFID tag activates to transmit a unique signal to a relay device which transmits a time-stamped message to a cloud-based server that functions as a direct measure of medication adherence. We describe a constellation of mobile technologies that provide real-time direct measures of medication adherence. Optimizing connectivity, relay design, and interactivity with users are important in obtaining maximal acceptability. Potential concerns including gut retention of metallic components of the ingestible biosensor and drug dissolution within a gelatin capsule should be considered. An ingestible biosensor incorporated into a medication management system has the potential to improve medication compliance with real-time monitoring of ingestion and prompt early behavioral intervention. Integration of ingestible biosensors for multiple disease states may provide toxicologists with salient data early in the care of poisoned patients in the future. Further research on device design and interventions to improve adherence is needed and will shape the evolving world of medication adherence. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 40% |
| Canada | 1 | 10% |
| United Kingdom | 1 | 10% |
| Unknown | 4 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 5 | 50% |
| Scientists | 2 | 20% |
| Members of the public | 2 | 20% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 65 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 23% |
| Student > Master | 8 | 12% |
| Student > Bachelor | 7 | 11% |
| Researcher | 6 | 9% |
| Student > Doctoral Student | 2 | 3% |
| Other | 7 | 11% |
| Unknown | 21 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 9% |
| Engineering | 5 | 8% |
| Agricultural and Biological Sciences | 4 | 6% |
| Nursing and Health Professions | 4 | 6% |
| Business, Management and Accounting | 4 | 6% |
| Other | 18 | 27% |
| Unknown | 25 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2023.
All research outputs
#3,342,627
of 23,394,907 outputs
Outputs from Journal of Medical Toxicology
#243
of 681 outputs
Outputs of similar age
#44,565
of 265,307 outputs
Outputs of similar age from Journal of Medical Toxicology
#7
of 13 outputs
Altmetric has tracked 23,394,907 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 681 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.5. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,307 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.