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Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents

Overview of attention for article published in Cancer and Metastasis Reviews, June 2018
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About this Attention Score

  • High Attention Score compared to outputs of the same age and source (80th percentile)

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1 X user

Citations

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32 Dimensions

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53 Mendeley
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Title
Functional link between plasma membrane spatiotemporal dynamics, cancer biology, and dietary membrane-altering agents
Published in
Cancer and Metastasis Reviews, June 2018
DOI 10.1007/s10555-018-9733-1
Pubmed ID
Authors

Alfredo Erazo-Oliveras, Natividad R. Fuentes, Rachel C. Wright, Robert S. Chapkin

Abstract

The cell plasma membrane serves as a nexus integrating extra- and intracellular components, which together enable many of the fundamental cellular signaling processes that sustain life. In order to perform this key function, plasma membrane components assemble into well-defined domains exhibiting distinct biochemical and biophysical properties that modulate various signaling events. Dysregulation of these highly dynamic membrane domains can promote oncogenic signaling. Recently, it has been demonstrated that select membrane-targeted dietary bioactives (MTDBs) have the ability to remodel plasma membrane domains and subsequently reduce cancer risk. In this review, we focus on the importance of plasma membrane domain structural and signaling functionalities as well as how loss of membrane homeostasis can drive aberrant signaling. Additionally, we discuss the intricacies associated with the investigation of these membrane domain features and their associations with cancer biology. Lastly, we describe the current literature focusing on MTDBs, including mechanisms of chemoprevention and therapeutics in order to establish a functional link between these membrane-altering biomolecules, tuning of plasma membrane hierarchal organization, and their implications in cancer prevention.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 19%
Student > Doctoral Student 7 13%
Researcher 7 13%
Student > Bachelor 5 9%
Professor 3 6%
Other 8 15%
Unknown 13 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 32%
Medicine and Dentistry 7 13%
Agricultural and Biological Sciences 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Nursing and Health Professions 1 2%
Other 4 8%
Unknown 19 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2018.
All research outputs
#15,683,389
of 23,305,591 outputs
Outputs from Cancer and Metastasis Reviews
#619
of 822 outputs
Outputs of similar age
#210,539
of 330,523 outputs
Outputs of similar age from Cancer and Metastasis Reviews
#3
of 10 outputs
Altmetric has tracked 23,305,591 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 822 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,523 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.