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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Disrupted development and integrity of frontal white matter in patients treated for pediatric medulloblastoma
|
|---|---|
| Published in |
Neuro-Oncology, May 2017
|
| DOI | 10.1093/neuonc/nox062 |
| Pubmed ID | |
| Authors |
John O Glass, Robert J Ogg, Jung W Hyun, Julie H Harreld, Jane E Schreiber, Shawna L Palmer, Yimei Li, Amar J Gajjar, Wilburn E Reddick |
| Abstract |
Treatment of pediatric medulloblastoma is associated with known neurocognitive deficits that we hypothesize are caused by microstructural damage to frontal white matter (WM). Longitudinal MRI examinations were collected from baseline (after surgery but before therapy) to 36 months in 146 patients and at 3 time points in 72 controls. Regional analyses of frontal WM volume and diffusion tensor imaging metrics were performed and verified with tract-based spatial statistics. Age-adjusted, linear mixed-effects models were used to compare patient and control images and to associate imaging changes with Woodcock-Johnson Tests of Cognitive Abilities. At baseline, WM volumes in patients were similar to those in controls; fractional anisotropy (FA) was lower bilaterally (P < 0.001) and was associated with decreased Processing Speed (P = 0.014) and Broad Attention (P = 0.025) performance at 36 months. During follow-up, WM volumes increased in controls but decreased in patients (P < 0.001) bilaterally. Smaller WM volumes in patients at 36 months were associated with concurrent decreased Working Memory (P = 0.026) performance. Lower FA in patients with pediatric medulloblastoma compared with age-similar controls indicated that patients suffer substantial acute microstructural damage to supratentorial frontal WM following surgery but before radiation therapy or chemotherapy. Additionally, this damage to the frontal WM was associated with decreased cognitive performance in executive function 36 months later. This early damage also likely contributed to posttherapeutic failure of age-appropriate WM development and to the known association between decreased WM volumes and decreased cognitive performance. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 80 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 16% |
| Student > Doctoral Student | 9 | 11% |
| Researcher | 8 | 10% |
| Student > Master | 5 | 6% |
| Student > Bachelor | 4 | 5% |
| Other | 11 | 14% |
| Unknown | 31 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 13 | 16% |
| Medicine and Dentistry | 10 | 12% |
| Neuroscience | 9 | 11% |
| Nursing and Health Professions | 3 | 4% |
| Unspecified | 3 | 4% |
| Other | 8 | 10% |
| Unknown | 35 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2018.
All research outputs
#15,010,626
of 23,090,520 outputs
Outputs from Neuro-Oncology
#1,915
of 3,270 outputs
Outputs of similar age
#187,003
of 313,879 outputs
Outputs of similar age from Neuro-Oncology
#52
of 75 outputs
Altmetric has tracked 23,090,520 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,270 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,879 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.