| Title |
Within-strain variation in behavior differs consistently between common inbred strains of mice
|
|---|---|
| Published in |
Mammalian Genome, June 2015
|
| DOI | 10.1007/s00335-015-9578-7 |
| Pubmed ID | |
| Authors |
Maarten Loos, Bastijn Koopmans, Emmeke Aarts, Gregoire Maroteaux, Sophie van der Sluis, Neuro-BSIK Mouse Phenomics Consortium, Matthijs Verhage, August B. Smit |
| Abstract |
Genetic and environmental factors interact throughout life and give rise to individual differences, i.e., individuality. The diversifying effect of environmental factors is counteracted by genetic mechanisms to yield persistence of specific features (robustness). Here, we compared robustness between cohorts of isogenic mice of eight different commonly used strains by analyzing to what extent environmental variation contributed to individuality in each of the eight genotypes, using a previously published dataset. Behavior was assessed in the home-cage, providing control over environmental factors, to reveal within-strain variability in numerous spontaneous behaviors. Indeed, despite standardization and in line with previous studies, substantial variability among mice of the same inbred strain was observed. Strikingly, across a multidimensional set of 115 behavioral parameters, several strains consistently ranked high in within-strain variability (DBA/2J, 129S1/Sv A/J and NOD/LtJ), whereas other strains ranked low (C57BL/6J and BALB/c). Strain rankings of within-strain variability in behavior were confirmed in an independent, previously published behavioral dataset using conventional behavioral tests administered to different mice from the same breeding colonies. Together, these show that genetically inbred mouse strains consistently differ in phenotypic robustness against environmental variation, suggesting that genetic factors contribute to variation in robustness. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Netherlands | 1 | 2% |
| Switzerland | 1 | 2% |
| Unknown | 59 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 27% |
| Student > Bachelor | 9 | 15% |
| Researcher | 9 | 15% |
| Student > Doctoral Student | 5 | 8% |
| Student > Master | 5 | 8% |
| Other | 5 | 8% |
| Unknown | 12 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 27% |
| Neuroscience | 12 | 19% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Veterinary Science and Veterinary Medicine | 3 | 5% |
| Environmental Science | 2 | 3% |
| Other | 9 | 15% |
| Unknown | 15 | 24% |
Attention Score in Context
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#18,422,065
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Outputs from Mammalian Genome
#1,004
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#189,031
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Outputs of similar age from Mammalian Genome
#17
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