| Title |
Effects of Δ9-THC and cannabidiol vapor inhalation in male and female rats
|
|---|---|
| Published in |
Psychopharmacology, June 2018
|
| DOI | 10.1007/s00213-018-4946-0 |
| Pubmed ID | |
| Authors |
Mehrak Javadi-Paydar, Jacques D. Nguyen, Tony M. Kerr, Yanabel Grant, Sophia A. Vandewater, Maury Cole, Michael A. Taffe |
| Abstract |
Previous studies report sex differences in some, but not all, responses to cannabinoids in rats. The majority of studies use parenteral injection; however, most human use is via smoke inhalation and, increasingly, vapor inhalation. To compare thermoregulatory and locomotor responses to inhaled ∆9-tetrahydrocannabinol (THC), cannabidiol (CBD), and their combination using an e-cigarette-based model in male and female rats METHODS: Male and female Wistar rats were implanted with radiotelemetry devices for the assessment of body temperature and locomotor activity. Animals were then exposed to THC or CBD vapor using a propylene glycol (PG) vehicle. THC dose was adjusted via the concentration in the vehicle (12.5-200 mg/mL) and the CBD (100, 400 mg/mL) dose was also adjusted by varying the inhalation duration (10-40 min). Anti-nociception was evaluated using a tail-withdrawal assay following vapor inhalation. Plasma samples obtained following inhalation in different groups of rats were compared for THC content. THC inhalation reduced body temperature and increased tail-withdrawal latency in both sexes equivalently and in a concentration-dependent manner. Female temperature, activity, and tail-withdrawal responses to THC did not differ between estrus and diestrus. CBD inhalation alone induced modest hypothermia and suppressed locomotor activity in both males and females. Co-administration of THC with CBD, in a 1:4 ratio, significantly decreased temperature and activity in an approximately additive manner and to similar extent in each sex. Plasma THC varied with the concentration in the PG vehicle but did not differ across rat sex. In summary, the inhalation of THC or CBD, alone and in combination, produces approximately equivalent effects in male and female rats. This confirms the efficacy of the e-cigarette-based method of THC delivery in female rats. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Japan | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 99 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 19% |
| Student > Ph. D. Student | 12 | 12% |
| Student > Master | 8 | 8% |
| Student > Doctoral Student | 7 | 7% |
| Researcher | 7 | 7% |
| Other | 12 | 12% |
| Unknown | 34 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 16 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 11% |
| Psychology | 6 | 6% |
| Agricultural and Biological Sciences | 5 | 5% |
| Medicine and Dentistry | 5 | 5% |
| Other | 20 | 20% |
| Unknown | 36 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2020.
All research outputs
#4,097,010
of 25,305,422 outputs
Outputs from Psychopharmacology
#1,065
of 5,649 outputs
Outputs of similar age
#66,926
of 308,929 outputs
Outputs of similar age from Psychopharmacology
#13
of 40 outputs
Altmetric has tracked 25,305,422 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,649 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one has done well, scoring higher than 81% of its peers.
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We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.