| Title |
Fructose and uric acid in diabetic nephropathy
|
|---|---|
| Published in |
Diabetologia, June 2015
|
| DOI | 10.1007/s00125-015-3650-4 |
| Pubmed ID | |
| Authors |
Petter Bjornstad, Miguel A. Lanaspa, Takuji Ishimoto, Tomoki Kosugi, Shinji Kume, Diana Jalal, David M. Maahs, Janet K. Snell-Bergeon, Richard J. Johnson, Takahiko Nakagawa |
| Abstract |
Clinical studies have reported associations between serum uric acid levels and the development of diabetic nephropathy, but the underlying mechanisms remain elusive. There is evidence from animal studies that blocking uric acid production protects the kidney from tubulointerstitial injury, which may suggest a causal role for uric acid in the development of diabetic tubular injury. In turn, when fructose, which is endogenously produced in diabetes via the polyol pathway, is metabolised, uric acid is generated from a side-chain reaction driven by ATP depletion and purine nucleotide turnover. For this reason, uric acid derived from endogenous fructose could cause tubulointerstitial injury in diabetes. Accordingly, our research group recently demonstrated that blocking fructose metabolism in a diabetic mouse model mitigated the development of tubulointerstitial injury by lowering tubular uric acid production. In this review we discuss the relationship between uric acid and fructose as a novel mechanism for the development of diabetic tubular injury. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 84 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 18% |
| Student > Ph. D. Student | 11 | 13% |
| Researcher | 10 | 12% |
| Professor > Associate Professor | 7 | 8% |
| Student > Bachelor | 5 | 6% |
| Other | 19 | 23% |
| Unknown | 17 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 37% |
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Agricultural and Biological Sciences | 11 | 13% |
| Nursing and Health Professions | 3 | 4% |
| Immunology and Microbiology | 3 | 4% |
| Other | 8 | 10% |
| Unknown | 17 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2023.
All research outputs
#15,297,447
of 23,524,722 outputs
Outputs from Diabetologia
#4,490
of 5,138 outputs
Outputs of similar age
#149,305
of 267,742 outputs
Outputs of similar age from Diabetologia
#55
of 77 outputs
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