Title |
Association study of GRM7 polymorphisms and schizophrenia in the Chinese Han population
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Published in |
Neuroscience Letters, August 2015
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DOI | 10.1016/j.neulet.2015.07.047 |
Pubmed ID | |
Authors |
Weibo Niu, Xiaoye Huang, Tao Yu, Shiqing Chen, Xingwang Li, Xi Wu, Yanfei Cao, Rui Zhang, Yan Bi, Fengping Yang, Lu Wang, Weidong Li, Yifeng Xu, Lin He, Guang He |
Abstract |
Schizophrenia is a severe and complex mental disorder with high heritability. There is an evidence that metabotropic glutamate receptors (GRM) are associated with schizophrenia. GRM7 has been identified as a candidate gene for many psychiatric disorders especially schizophrenia. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in GRM7 were associated with schizophrenia. Four SNPs (rs9814881, rs13353402, rs9870680 and rs1531939) were genotyped in 1034 schizophrenic patients and 1034 healthy controls of Chinese Han origin. The results showed that the two SNPs rs13353402 and rs1531939 demonstrated significant difference between schizophrenic patients and control subjects in allele frequencies (rs13353402: P value = 0.0307, rs1531939: P value = 0.0328, respectively). Nevertheless, there was no significant discrepancies in genotype distribution. In summary, our results indicate that the GRM7 SNPs rs13353402 and rs1531939 might be associated with schizophrenia in Chinese Han population. |
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