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Association study of GRM7 polymorphisms and schizophrenia in the Chinese Han population

Overview of attention for article published in Neuroscience Letters, August 2015
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Title
Association study of GRM7 polymorphisms and schizophrenia in the Chinese Han population
Published in
Neuroscience Letters, August 2015
DOI 10.1016/j.neulet.2015.07.047
Pubmed ID
Authors

Weibo Niu, Xiaoye Huang, Tao Yu, Shiqing Chen, Xingwang Li, Xi Wu, Yanfei Cao, Rui Zhang, Yan Bi, Fengping Yang, Lu Wang, Weidong Li, Yifeng Xu, Lin He, Guang He

Abstract

Schizophrenia is a severe and complex mental disorder with high heritability. There is an evidence that metabotropic glutamate receptors (GRM) are associated with schizophrenia. GRM7 has been identified as a candidate gene for many psychiatric disorders especially schizophrenia. In this study, we investigated whether single nucleotide polymorphisms (SNPs) in GRM7 were associated with schizophrenia. Four SNPs (rs9814881, rs13353402, rs9870680 and rs1531939) were genotyped in 1034 schizophrenic patients and 1034 healthy controls of Chinese Han origin. The results showed that the two SNPs rs13353402 and rs1531939 demonstrated significant difference between schizophrenic patients and control subjects in allele frequencies (rs13353402: P value = 0.0307, rs1531939: P value = 0.0328, respectively). Nevertheless, there was no significant discrepancies in genotype distribution. In summary, our results indicate that the GRM7 SNPs rs13353402 and rs1531939 might be associated with schizophrenia in Chinese Han population.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 21%
Student > Ph. D. Student 2 11%
Researcher 2 11%
Student > Postgraduate 2 11%
Student > Master 2 11%
Other 4 21%
Unknown 3 16%
Readers by discipline Count As %
Neuroscience 4 21%
Biochemistry, Genetics and Molecular Biology 3 16%
Medicine and Dentistry 3 16%
Psychology 2 11%
Nursing and Health Professions 1 5%
Other 2 11%
Unknown 4 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2015.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Neuroscience Letters
#6,782
of 7,756 outputs
Outputs of similar age
#236,070
of 275,990 outputs
Outputs of similar age from Neuroscience Letters
#67
of 100 outputs
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