| Title |
Probiotics L. acidophilus and B. clausii Modulate Gut Microbiota in Th1- and Th2-Biased Mice to Ameliorate Salmonella Typhimurium-Induced Diarrhea
|
|---|---|
| Published in |
Probiotics and Antimicrobial Proteins, June 2018
|
| DOI | 10.1007/s12602-018-9436-5 |
| Pubmed ID | |
| Authors |
Biswaranjan Pradhan, Dipanjan Guha, Aman Kumar Naik, Arka Banerjee, Subodh Tambat, Saurabh Chawla, Shantibhusan Senapati, Palok Aich |
| Abstract |
Gut microbiota play important role in maintaining health. Probiotics are believed to augment it further. We aimed at comparing effects of probiotics, Lactobacillus acidophilus (LA) and Bacillus clausii (BC) (a) on the gut microbiota abundance and diversity and (b) their contributions to control intestinal dysbiosis and inflammation in Th1- and Th2-biased mice following Salmonella infection. We report how could gut microbiota and the differential immune bias (Th1 or Th2) of the host regulate host responses when challenged with Salmonella typhimurium in the presence and absence of either of the probiotics. LA was found to be effective in ameliorating the microbial dysbiosis and inflammation caused by Salmonella infection, in Th1 (C57BL/6) and Th2 (BALB/c)-biased mouse. BC was able to ameliorate Salmonella-induced dysbiosis and inflammation in Th2 but not in Th1-biased mouse. These results may support probiotics LA as a treatment option in the case of Salmonella infection. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 17% |
| Unknown | 5 | 83% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 12% |
| Student > Ph. D. Student | 6 | 11% |
| Student > Doctoral Student | 5 | 9% |
| Researcher | 5 | 9% |
| Student > Bachelor | 3 | 5% |
| Other | 7 | 12% |
| Unknown | 24 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 8 | 14% |
| Biochemistry, Genetics and Molecular Biology | 6 | 11% |
| Agricultural and Biological Sciences | 5 | 9% |
| Medicine and Dentistry | 4 | 7% |
| Nursing and Health Professions | 1 | 2% |
| Other | 6 | 11% |
| Unknown | 27 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2020.
All research outputs
#2,731,052
of 23,090,520 outputs
Outputs from Probiotics and Antimicrobial Proteins
#30
of 548 outputs
Outputs of similar age
#53,352
of 301,972 outputs
Outputs of similar age from Probiotics and Antimicrobial Proteins
#2
of 21 outputs
Altmetric has tracked 23,090,520 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 548 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done particularly well, scoring higher than 94% of its peers.
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We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.