| Title |
Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans
|
|---|---|
| Published in |
Diabetologia, August 2015
|
| DOI | 10.1007/s00125-015-3705-6 |
| Pubmed ID | |
| Authors |
Erin L. Glynn, Lucy W. Piner, Kim M. Huffman, Cris A. Slentz, Lorraine Elliot-Penry, Hiba AbouAssi, Phillip J. White, James R. Bain, Michael J. Muehlbauer, Olga R. Ilkayeva, Robert D. Stevens, Kathryn N. Porter Starr, Connie W. Bales, Elena Volpi, M. Julia Brosnan, Jeff K. Trimmer, Timothy P. Rolph, Christopher B. Newgard, William E. Kraus |
| Abstract |
Obesity is associated with decreased insulin sensitivity (IS) and elevated plasma branched-chain amino acids (BCAAs). The purpose of this study was to investigate the relationship between BCAA metabolism and IS in overweight (OW) individuals during exercise intervention. Whole-body leucine turnover, IS by hyperinsulinaemic-euglycaemic clamp, and circulating and skeletal muscle amino acids, branched-chain α-keto acids and acylcarnitines were measured in ten healthy controls (Control) and nine OW, untrained, insulin-resistant individuals (OW-Untrained). OW-Untrained then underwent a 6 month aerobic and resistance exercise programme and repeated testing (OW-Trained). IS was higher in Control vs OW-Untrained and increased significantly following exercise. IS was lower in OW-Trained vs Control expressed relative to body mass, but was not different from Control when normalised to fat-free mass (FFM). Plasma BCAAs and leucine turnover (relative to FFM) were higher in OW-Untrained vs Control, but did not change on average with exercise. Despite this, within individuals, the decrease in molar sum of circulating BCAAs was the best metabolic predictor of improvement in IS. Circulating glycine levels were higher in Control and OW-Trained vs OW-Untrained, and urinary metabolic profiling suggests that exercise induces more efficient elimination of excess acyl groups derived from BCAA and aromatic amino acid (AA) metabolism via formation of urinary glycine adducts. A mechanism involving more efficient elimination of excess acyl groups derived from BCAA and aromatic AA metabolism via glycine conjugation in the liver, rather than increased BCAA disposal through oxidation and turnover, may mediate interactions between exercise, BCAA metabolism and IS. Clinicaltrials.gov NCT01786941. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 17% |
| Australia | 3 | 13% |
| United States | 2 | 9% |
| Norway | 1 | 4% |
| Sweden | 1 | 4% |
| Qatar | 1 | 4% |
| Germany | 1 | 4% |
| Unknown | 10 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 57% |
| Scientists | 9 | 39% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 164 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Chile | 1 | <1% |
| Germany | 1 | <1% |
| Mexico | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 158 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 23 | 14% |
| Student > Ph. D. Student | 21 | 13% |
| Researcher | 21 | 13% |
| Student > Master | 16 | 10% |
| Student > Doctoral Student | 10 | 6% |
| Other | 34 | 21% |
| Unknown | 39 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 18% |
| Biochemistry, Genetics and Molecular Biology | 23 | 14% |
| Sports and Recreations | 22 | 13% |
| Agricultural and Biological Sciences | 19 | 12% |
| Nursing and Health Professions | 14 | 9% |
| Other | 14 | 9% |
| Unknown | 43 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2015.
All research outputs
#2,759,357
of 25,401,381 outputs
Outputs from Diabetologia
#1,379
of 5,348 outputs
Outputs of similar age
#34,506
of 275,663 outputs
Outputs of similar age from Diabetologia
#19
of 72 outputs
Altmetric has tracked 25,401,381 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
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