| Title |
Glial regulation of the blood-brain barrier in health and disease
|
|---|---|
| Published in |
Seminars in Immunopathology, August 2015
|
| DOI | 10.1007/s00281-015-0516-2 |
| Pubmed ID | |
| Authors |
Bieke Broux, Elizabeth Gowing, Alexandre Prat |
| Abstract |
The brain is the organ with the highest metabolic demand in the body. Therefore, it needs specialized vasculature to provide it with the necessary oxygen and nutrients, while protecting it against pathogens and toxins. The blood-brain barrier (BBB) is very tightly regulated by specialized endothelial cells, two basement membranes, and astrocytic endfeet. The proximity of astrocytes to the vessel makes them perfect candidates to influence the function of the BBB. Moreover, other glial cells are also known to contribute to either BBB quiescence or breakdown. In this review, we summarize the knowledge on glial regulation of the BBB during development, in homeostatic conditions in the adult, and during neuroinflammatory responses. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Greece | 1 | 1% |
| Unknown | 71 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 30% |
| Student > Master | 14 | 19% |
| Researcher | 6 | 8% |
| Student > Bachelor | 6 | 8% |
| Student > Postgraduate | 4 | 5% |
| Other | 12 | 16% |
| Unknown | 9 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 16 | 22% |
| Agricultural and Biological Sciences | 13 | 18% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Medicine and Dentistry | 8 | 11% |
| Immunology and Microbiology | 4 | 5% |
| Other | 10 | 14% |
| Unknown | 14 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2015.
All research outputs
#18,422,065
of 22,821,814 outputs
Outputs from Seminars in Immunopathology
#432
of 547 outputs
Outputs of similar age
#189,905
of 264,036 outputs
Outputs of similar age from Seminars in Immunopathology
#14
of 20 outputs
Altmetric has tracked 22,821,814 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 547 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,036 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.