| Title |
Albumin in chronic liver disease: structure, functions and therapeutic implications
|
|---|---|
| Published in |
Hepatology International, September 2015
|
| DOI | 10.1007/s12072-015-9665-6 |
| Pubmed ID | |
| Authors |
Rosaria Spinella, Rohit Sawhney, Rajiv Jalan |
| Abstract |
Human serum albumin is a critical plasma protein produced by the liver with a number of accepted clinical indications in chronic liver disease including management of circulatory and renal dysfunction in patients with ascites. Advanced cirrhosis is characterised by reduced albumin concentration as well as impaired albumin function as a result of specific structural changes and oxidative damage. Traditionally, the biologic and therapeutic role of albumin in liver disease was attributed to its oncotic effects but it is now understood that albumin has a wide range of other important physiologic functions such as immunomodulation, endothelial stabilisation, antioxidant effects and binding multiple drugs, toxins and other molecules. This review discusses the multifunctional properties of albumin and, in particular, the biologic and clinical implications of structural and functional changes of albumin that are associated with cirrhosis. Based on these insights, we explore the current and potential future therapeutic uses of albumin in liver disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 229 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 229 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 30 | 13% |
| Student > Master | 25 | 11% |
| Student > Ph. D. Student | 22 | 10% |
| Researcher | 21 | 9% |
| Other | 11 | 5% |
| Other | 30 | 13% |
| Unknown | 90 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 17% |
| Biochemistry, Genetics and Molecular Biology | 25 | 11% |
| Agricultural and Biological Sciences | 17 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 4% |
| Chemistry | 7 | 3% |
| Other | 35 | 15% |
| Unknown | 96 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2023.
All research outputs
#3,112,828
of 24,462,749 outputs
Outputs from Hepatology International
#44
of 587 outputs
Outputs of similar age
#41,465
of 279,544 outputs
Outputs of similar age from Hepatology International
#2
of 5 outputs
Altmetric has tracked 24,462,749 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 587 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,544 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.