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Mendeley readers
| Title |
Structural Chromosome Abnormalities Associated with Obesity: Report of Four New subjects and Review of Literature
|
|---|---|
| Published in |
Current Genomics, May 2011
|
| DOI | 10.2174/138920211795677930 |
| Pubmed ID | |
| Authors |
Majed J Dasouki, Erin L Youngs, Karine Hovanes |
| Abstract |
Obesity in humans is a complex polygenic trait with high inter-individual heritability estimated at 40-70%. Candidate gene, DNA linkage and genome-wide association studies (GWAS) have allowed for the identification of a large set of genes and genomic regions associated with obesity. Structural chromosome abnormalities usually result in congenital anomalies, growth retardation and developmental delay. Occasionally, they are associated with hyperphagia and obesity rather than growth delay. We report four new individuals with structural chromosome abnormalities involving 10q22.3-23.2, 16p11.2 and Xq27.1-q28 chromosomal regions with early childhood obesity and developmental delay. We also searched and summarized the literature for structural chromosome abnormalities reported in association with childhood obesity. |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 6% |
| Italy | 1 | 3% |
| Unknown | 33 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 25% |
| Student > Ph. D. Student | 7 | 19% |
| Student > Bachelor | 4 | 11% |
| Other | 4 | 11% |
| Student > Doctoral Student | 2 | 6% |
| Other | 6 | 17% |
| Unknown | 4 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 28% |
| Agricultural and Biological Sciences | 7 | 19% |
| Biochemistry, Genetics and Molecular Biology | 4 | 11% |
| Neuroscience | 4 | 11% |
| Social Sciences | 3 | 8% |
| Other | 4 | 11% |
| Unknown | 4 | 11% |