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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Population Pharmacokinetics of Fosfomycin in Critically Ill Patients
|
|---|---|
| Published in |
Antimicrobial Agents and Chemotherapy, August 2015
|
| DOI | 10.1128/aac.01321-15 |
| Pubmed ID | |
| Authors |
Suzanne L. Parker, Frantzeska Frantzeskaki, Steven C. Wallis, Chryssa Diakaki, Helen Giamarellou, Despoina Koulenti, Ilias Karaiskos, Jeffrey Lipman, George Dimopoulos, Jason A. Roberts |
| Abstract |
This study describes the population pharmacokinetics of fosfomycin in critically ill patients. In this observational study, serial blood samples were taken over several dosing intervals of intravenous fosfomycin. Blood samples were analysed using a validated liquid chromatography tandem mass spectrometry technique. A population pharmacokinetic analysis was performed using non-linear mixed effects modeling. Five hundred and fifteen blood samples were collected over one to six dosing intervals from 12 patients. The mean (SD) age was 62 (17) years, 67% were male and creatinine clearance (CLCR) ranged from 30 to 300 mL/min. A two-compartment model with between-subject variability on clearance and volume of distribution of the central compartment (Vc) described the data adequately. Calculated CLCR was supported as a covariate on fosfomycin clearance. The mean parameter estimates for clearance on the first day were 2.06 L/h, Vc 27.2 L, intercompartmental clearance 19.8 L/h and volume of the peripheral compartment 22.3 L. We found significant pharmacokinetic variability of fosfomycin in this heterogeneous patient sample, which may be explained somewhat by the observed variations in renal function. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 43% |
| United Kingdom | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 57% |
| Practitioners (doctors, other healthcare professionals) | 3 | 43% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 1% |
| Unknown | 68 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 17% |
| Student > Ph. D. Student | 10 | 14% |
| Other | 8 | 12% |
| Student > Master | 7 | 10% |
| Student > Postgraduate | 5 | 7% |
| Other | 9 | 13% |
| Unknown | 18 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 32% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 22% |
| Agricultural and Biological Sciences | 4 | 6% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Immunology and Microbiology | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 23 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2016.
All research outputs
#3,750,899
of 25,371,288 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#3,035
of 15,580 outputs
Outputs of similar age
#45,753
of 275,737 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#24
of 238 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,580 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,737 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 238 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.