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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Non-antibiotic antimicrobial triclosan induces multiple antibiotic resistance through genetic mutation
|
|---|---|
| Published in |
Environment International, June 2018
|
| DOI | 10.1016/j.envint.2018.06.004 |
| Pubmed ID | |
| Authors |
Ji Lu, Min Jin, Son Hoang Nguyen, Likai Mao, Jie Li, Lachlan J.M. Coin, Zhiguo Yuan, Jianhua Guo |
| Abstract |
Antibiotic resistance poses a major threat to public health. Overuse and misuse of antibiotics are generally recognized as the key factors contributing to antibiotic resistance. However, whether non-antibiotic, anti-microbial (NAAM) chemicals can directly induce antibiotic resistance is unclear. We aim to investigate whether the exposure to a NAAM chemical triclosan (TCS) has an impact on inducing antibiotic resistance on Escherichia coli. Here, we report that at a concentration of 0.2 mg/L TCS induces multi-drug resistance in wild-type Escherichia coli after 30-day TCS exposure. The oxidative stress induced by TCS caused genetic mutations in genes such as fabI, frdD, marR, acrR and soxR, and subsequent up-regulation of the transcription of genes encoding beta-lactamases and multi-drug efflux pumps, together with down-regulation of genes related to membrane permeability. The findings advance our understanding of the potential role of NAAM chemicals in the dissemination of antibiotic resistance in microbes, and highlight the need for controlling biocide applications. |
X Demographics
The data shown below were collected from the profiles of 49 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 18% |
| France | 9 | 18% |
| Turkey | 1 | 2% |
| Ireland | 1 | 2% |
| Japan | 1 | 2% |
| Germany | 1 | 2% |
| Sweden | 1 | 2% |
| Australia | 1 | 2% |
| Italy | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 23 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 36 | 73% |
| Scientists | 7 | 14% |
| Practitioners (doctors, other healthcare professionals) | 6 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 195 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 195 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 27 | 14% |
| Student > Ph. D. Student | 24 | 12% |
| Student > Bachelor | 24 | 12% |
| Student > Master | 17 | 9% |
| Student > Doctoral Student | 8 | 4% |
| Other | 23 | 12% |
| Unknown | 72 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 14% |
| Environmental Science | 23 | 12% |
| Agricultural and Biological Sciences | 11 | 6% |
| Immunology and Microbiology | 10 | 5% |
| Medicine and Dentistry | 7 | 4% |
| Other | 29 | 15% |
| Unknown | 88 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 242. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2021.
All research outputs
#154,764
of 25,382,440 outputs
Outputs from Environment International
#92
of 5,189 outputs
Outputs of similar age
#3,357
of 341,432 outputs
Outputs of similar age from Environment International
#3
of 101 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,189 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,432 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.