| Title |
Evaluation of ostarine as a selective androgen receptor modulator in a rat model of postmenopausal osteoporosis
|
|---|---|
| Published in |
Journal of Bone and Mineral Metabolism, May 2018
|
| DOI | 10.1007/s00774-018-0929-9 |
| Pubmed ID | |
| Authors |
D. B. Hoffmann, M. Komrakova, S. Pflug, M. von Oertzen, D. Saul, L. Weiser, T. A. Walde, M. Wassmann, A. F. Schilling, W. Lehmann, S. Sehmisch |
| Abstract |
Selective androgen receptor modulators (SARMs) have shown beneficial effects on muscle wasting, general physical function and bone properties in male mammals. However, data on the effects of SARMs in postmenopausal osteoporotic bone are scarce. We evaluated the effects of the SARM drug ostarine on postmenopausal osteoporotic bone in a rat osteoporosis model. Ovariectomy was performed on 46 of 56 3-month-old female Sprague-Dawley rats. Eight weeks after ovariectomy, ostarine was orally administered daily for 5 weeks in dosages of 0.04 (low, OVX + Ost. 0.04), 0.4 (intermediate, OVX + Ost. 0.4), and 4 mg/kg (high, OVX + Ost. 4) body weight. Another ovariectomized group received no ostarine. Lumbar vertebrae and femora were removed for biomechanical, gene expression, ashing, and computer tomography analyses. Low dose showed no effects. The effects of intermediate and high doses were comparable overall. Improvements were mainly seen in structural properties such as bone mineral density and bone volume density. However, the effects in femora were superior to effects in vertebrae. Ostarine treatment for 5 weeks did not improve significantly biomechanical properties. mRNA expression of the receptor activator of NF-κB ligand decreased after treatment, and uterine weight increased. Serum levels of phosphorus increased following ostarine treatment in intermediate and high-dose groups. Short-term treatment of osteoporotic bone with ostarine leads to improvement of several microstructural bone indices. While we did not observe changes in biomechanics, it is conceivable that longer treatment may also improve biomechanical properties. Further studies are needed to characterize longer time effects and side effects of ostarine in osteoporosis. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Netherlands | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 44 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 9 | 20% |
| Student > Bachelor | 6 | 14% |
| Student > Ph. D. Student | 5 | 11% |
| Researcher | 4 | 9% |
| Student > Doctoral Student | 2 | 5% |
| Other | 6 | 14% |
| Unknown | 12 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 11% |
| Medicine and Dentistry | 5 | 11% |
| Nursing and Health Professions | 4 | 9% |
| Business, Management and Accounting | 2 | 5% |
| Other | 9 | 20% |
| Unknown | 14 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 September 2018.
All research outputs
#16,061,913
of 23,842,189 outputs
Outputs from Journal of Bone and Mineral Metabolism
#367
of 787 outputs
Outputs of similar age
#212,539
of 332,173 outputs
Outputs of similar age from Journal of Bone and Mineral Metabolism
#4
of 7 outputs
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