| Title |
The effect of melatonin on sleep and quality of life in patients with advanced breast cancer
|
|---|---|
| Published in |
Supportive Care in Cancer, August 2015
|
| DOI | 10.1007/s00520-015-2883-6 |
| Pubmed ID | |
| Authors |
Pasquale F. Innominato, Andrew S. Lim, Oxana Palesh, Mark Clemons, Maureen Trudeau, Andrea Eisen, Cathy Wang, Alex Kiss, Kathleen I. Pritchard, Georg A. Bjarnason |
| Abstract |
Fatigue and sleep problems are prevalent in cancer patients and can be associated with disruption of circadian rhythmicity. In this prospective phase II trial, we sought to assess the effect of melatonin on circadian biomarkers, sleep, and quality of life in breast cancer patients. Thirty-two patients with metastatic breast cancer, receiving hormonal or trastuzumab therapy, took 5 mg of melatonin at bedtime for 2 months. Before starting and after 2 months on melatonin therapy, sleep and circadian rhythmicity were assessed by actigraphy, diurnal patterns of serum cortisol, and the expression of the core clock genes PER2 and BMAL1 in peripheral blood mononuclear cells. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire was completed for subjective parameters. Bedtime melatonin was associated with a significant improvement in a marker of objective sleep quality, sleep fragmentation and quantity, subjective sleep, fatigue severity, global quality of life, and social and cognitive functioning scales. Morning clock gene expression was increased following bedtime melatonin intake. Melatonin did not affect actigraphy measure of circadian rhythmicity, or the diurnal cortisol pattern. These results invite further investigation of melatonin as a potentially useful therapeutic agent for improving sleep and quality of life in cancer patients. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 55% |
| Australia | 1 | 9% |
| United Kingdom | 1 | 9% |
| Unknown | 3 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 55% |
| Scientists | 3 | 27% |
| Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 185 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Italy | 1 | <1% |
| Sweden | 1 | <1% |
| Canada | 1 | <1% |
| China | 1 | <1% |
| Unknown | 180 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 27 | 15% |
| Student > Master | 18 | 10% |
| Student > Ph. D. Student | 17 | 9% |
| Researcher | 16 | 9% |
| Student > Doctoral Student | 11 | 6% |
| Other | 36 | 19% |
| Unknown | 60 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 24% |
| Nursing and Health Professions | 15 | 8% |
| Psychology | 14 | 8% |
| Agricultural and Biological Sciences | 11 | 6% |
| Biochemistry, Genetics and Molecular Biology | 10 | 5% |
| Other | 26 | 14% |
| Unknown | 64 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2022.
All research outputs
#2,249,513
of 24,400,706 outputs
Outputs from Supportive Care in Cancer
#370
of 4,886 outputs
Outputs of similar age
#29,069
of 268,990 outputs
Outputs of similar age from Supportive Care in Cancer
#6
of 90 outputs
Altmetric has tracked 24,400,706 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,886 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,990 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.