| Title |
Sex-Specific Contributions of Endothelin to Hypertension
|
|---|---|
| Published in |
Current Hypertension Reports, June 2018
|
| DOI | 10.1007/s11906-018-0856-0 |
| Pubmed ID | |
| Authors |
Eman Y. Gohar, David M. Pollock |
| Abstract |
Men and women differ in the prevalence, pathophysiology and control rate of hypertension in an age-dependent manner. The renal endothelin system plays a central role in sex differences in blood pressure regulation by control of sodium excretion and vascular function. Improving our understanding of the sex differences in the endothelin system, especially in regard to blood pressure regulation and sodium homeostasis, will fill a significant gap in our knowledge and may identify sex-specific therapeutic targets for management of hypertension. The current review will highlight evidence for the potential role for endothelin system in the pathophysiology of hypertension within three female populations: (i) postmenopausal women, (ii) women suffering from preeclampsia, or (iii) pulmonary arterial hypertension. Clinical trials that specifically address cardiovascular and renal diseases in females under different hormonal status are limited. Studies of the modulatory role of gonadal hormones and sex-specific mechanisms on critically important systems involved, such as endothelin, are needed to establish new clinical practice guidelines based on systematic evidence. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 45 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 20% |
| Researcher | 3 | 7% |
| Student > Master | 3 | 7% |
| Professor | 2 | 4% |
| Student > Ph. D. Student | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 24 | 53% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 9% |
| Nursing and Health Professions | 2 | 4% |
| Materials Science | 2 | 4% |
| Sports and Recreations | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 27 | 60% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2018.
All research outputs
#17,548,753
of 25,728,855 outputs
Outputs from Current Hypertension Reports
#515
of 793 outputs
Outputs of similar age
#222,288
of 343,171 outputs
Outputs of similar age from Current Hypertension Reports
#20
of 33 outputs
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